Prenatal alcohol exposure is associated with early motor, but not language development in a South African cohort
Author | Hendricks, Gaironeesa |
Author | Malcolm-Smith, Susan |
Author | Stein, Dan J. |
Author | Zar, Heather J. |
Author | Wedderburn, Catherine J. |
Author | Nhapi, Raymond T. |
Author | Chivese, Tawanda |
Author | Adnams, Colleen M. |
Author | Donald, Kirsten A. |
Available date | 2020-08-18T08:34:44Z |
Publication Date | 2019 |
Publication Name | Acta Neuropsychiatrica |
Resource | Scopus |
ISSN | 9242708 |
Abstract | Objective:To investigate the association of prenatal alcohol exposure (PAE) and early neurodevelopment in the first 2 years of life, adjusting for maternal sociodemographic and psychosocial factors, in the Drakenstein Child Health Study (DCHS), a South African birth cohort study.Methods:The DCHS comprises a population-based birth cohort of 1143 children, of which, a subsample completed the Bayley Scales of Infant Development-III (BSID-III) at 6 (n = 260) and 24 months of age (n = 734). A subset of alcohol exposed, and unexposed children was included in this analysis at age 6 months (n = 52 exposed; n = 104 unexposed) and 24 months (n = 92 exposed; n=184 unexposed). Multiple hierarchical regression was used to explore the associations of PAE with motor and language development.Results:PAE was significantly associated with decreased gross motor (OR = 0.16, 95%CI 0.06-0.44, p = 0.001) or fine motor (OR = 0.16, 95%CI 0.06-0.46, p = 0.001) functioning after adjusting for maternal sociodemographic and psychosocial factors at 6 months of age only. No significant effects were found in either receptive or expressive communication and cognitive outcomes at either time point.Conclusion:PAE has potentially important consequences for motor development in the first 2 years of life, a period during which the most rapid growth and maturation occurs. These findings highlight the importance of identifying high-risk families in order to provide preventive interventions, particularly in antenatal clinics and early intervention services. - 2020 Scandinavian College of Neuropsychopharmacology. |
Language | en |
Publisher | Cambridge University Press |
Subject | Language Development3 Motor Development2 Neurodevelopment4 Prenatal Alcohol Exposure1 |
Type | Article |
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