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AuthorLu, Shoutao
AuthorJun, Zhang
AuthorLi, Maoquan
AuthorHou, Wenbo
AuthorYin, Yuxia
AuthorZhou, Chao
AuthorLiu, Guang
AuthorDuan, Cuihai
AuthorToft, Egon Steen
AuthorZhang, Haijun
Available date2020-08-18T08:34:46Z
Publication Date2019
Publication NamePolymer-Plastics Technology and Materials
ResourceScopus
ISSN25740881
URIhttp://dx.doi.org/10.1080/03602559.2018.1542716
URIhttp://hdl.handle.net/10576/15682
AbstractDrug-eluting microspheres are the most commonly used particulate embolic agents for transarterial chemoembolization of liver tumors. However, drug loading of degradable embolic particles is often insufficient. In the current study, microspheres prepared from poly(D,L-lactic-co-glycolic acid) were investigated as a biodegradable embolic agent for arterial embolization applications. Through modified solvent evaporation and liquid-induced phase separation, high drug loading (as high as 32%) and low solvent residue (as low as 0.03%) was achieved. Degradation performance,1H NMR, and the nonsolvent's influence on solvent residue content were assessed. These drug-loading microspheres with biodegradability hold promise for embolization therapies. 50. - 2018 Taylor & Francis Group, LLC.
SponsorThis work was supported by NSFC (Grant No. 81771417), and National Science & Technology Pillar Program(Grant No. 2012BAI15B06)
Languageen
PublisherTaylor and Francis Inc.
SubjectDegradable
Embolization
Microsphere
Sustained release
TitleImproved liquid phase separation processes for generating biodegradable microspheres loaded with high concentrations of drugs for tumor embolization
TypeArticle
Pagination1005-1012
Issue Number9
Volume Number58
dc.accessType Abstract Only


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