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المؤلفGupta, Ishita
المؤلفGhabreau, Lina
المؤلفAl-Thawadi, Hamda
المؤلفYasmeen, Amber
المؤلفVranic, Semir
المؤلفAl Moustafa, Ala-Eddin
المؤلفMalki, Mohammed I
تاريخ الإتاحة2020-09-27T04:56:38Z
تاريخ النشر2020-08-20
اسم المنشورFrontiers in Oncology
المعرّفhttp://dx.doi.org/10.3389/fonc.2020.01016
الاقتباسGupta I, Ghabreau L, Al-Thawadi H, Yasmeen A, Vranic S, Al Moustafa A-E and Malki MI (2020) Co-incidence of Human Papillomaviruses and Epstein–Barr Virus Is Associated With High to Intermediate Tumor Grade in Human Head and Neck Cancer in Syria. Front. Oncol. 10:1016. doi: 10.3389/fonc.2020.01016
معرّف المصادر الموحدhttp://hdl.handle.net/10576/16307
الملخصHigh-risk human papillomaviruses (high-risk HPVs) have been recently reported to be co-present with Epstein-Barr virus (EBV) in different types of human cancers including head and neck (HN), where they can cooperate in the initiation and/or progression of this cancer. Accordingly, we herein explored the prevalence of high-risk HPVs and EBV in 80 HN cancer tissues from the Syrian population using polymerase chain reaction, immunohistochemistry, and tissue microarray methodologies. We report that high-risk HPVs and EBV are present in 35/80 (43.7%) and 41/80 (51.2%) of our samples, respectively, and the most frequent HPV types are 33, 16, 18, 45, 52, 58, 35, 51, and 31, in this order. More significantly, our data reveal that 25/80 (31.2%) of cancer cases are positive for high-risk HPVs as well as EBV, and their co-presence is associated with high/intermediate-grade squamous cell carcinomas. These data confirm the co-presence of high-risk HPVs and EBV in HN cancers in the Syrian population of the Middle East and demonstrate that their co-incidence is linked to a more aggressive cancer phenotype. Thus, future studies are required to confirm these data and elucidate the exact role of high-risk and EBV cooperation in human HN carcinogenesis.
راعي المشروعThis work was supported by Qatar University grants # QUHI-CMED-19/20-1 and GCC-2017-002 QU/KU.
اللغةen
الناشرFrontiers Media
الموضوعEpstein–Barr virus
Syrian population
head and neck cancers
human papillomaviruses
tumor grade
العنوانCo-incidence of Human Papillomaviruses and Epstein-Barr Virus Is Associated With High to Intermediate Tumor Grade in Human Head and Neck Cancer in Syria.
النوعArticle
الصفحات1016
رقم المجلد10
ESSN2234-943X
dc.accessType Open Access


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