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المؤلفGupta, Ishita
المؤلفJabeen, Ayesha
المؤلفAl-Sarraf, Reem
المؤلفFarghaly, Hanan
المؤلفVranic, Semir
المؤلفSultan, Ali A
المؤلفAl Moustafa, Ala-Eddin
المؤلفAl-Thawadi, Hamda
تاريخ الإتاحة2020-10-05T04:48:24Z
تاريخ النشر2020-10-02
اسم المنشورHuman Vaccines and Immunotherapeutics
المعرّفhttp://dx.doi.org/10.1080/21645515.2020.1802977
الاقتباسIshita Gupta, Ayesha Jabeen, Reem Al-Sarraf, Hanan Farghaly, Semir Vranic, Ali A. Sultan, Ala-Eddin Al Moustafa & Hamda Al-Thawadi (2020) The co-presence of high-risk human papillomaviruses and Epstein-Barr virus is linked with tumor grade and stage in Qatari women with breast cancer, Human Vaccines & Immunotherapeutics, DOI: 10.1080/21645515.2020.1802977
الرقم المعياري الدولي للكتاب2164-5515
معرّف المصادر الموحدhttp://hdl.handle.net/10576/16366
الملخصHigh-risk human papillomaviruses (HPV) can be present and cooperate with Epstein-Barr virus (EBV) to promote the onset and/or progression of various cancers including cervical, breast, head and neck as well as colorectal. In this investigation, we explored the co-prevalence of high-risk HPV and EBV in 74 breast cancer tissues from Qatari women using polymerase chain reaction. We found that high-risk HPV and EBV are present in 48/74 (65%) and 36/74 (49%) of the cases, respectively. While we noted that the presence of HPV presence is associated with triple-negative breast cancer (TNBC) ( = .008), however, the presence of EBV did not correlate with any breast cancer subgroup. Moreover, our data revealed that high-risk HPV and EBV are co-present in 35/74 (47%) of the samples and their co-presence is significantly associated with tumor grade ( = .04) and tumor stage ( = .04). These data indicate that HPV and EBV are commonly co-present in breast cancer and their association could be linked with a more aggressive tumor phenotype. Thus, further investigations are essential to understand the underlying mechanisms of HPV and EBV cooperation in breast carcinogenesis.
راعي المشروعgrants from Qatar University [QUCG-CMED-2018/2019-3, QUHI-CMED-19/20-1 and QUCG-CMED-20/21-2
اللغةen
الناشرTaylor and Francis
الموضوعEBV
HPV
Qatari population
breast cancer
tumor grade
tumor stage
العنوانThe co-presence of high-risk human papillomaviruses and Epstein-Barr virus is linked with tumor grade and stage in Qatari women with breast cancer.
النوعArticle
الصفحات1-8
ESSN2164-554X
dc.accessType Open Access


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