The co-presence of high-risk human papillomaviruses and Epstein-Barr virus is linked with tumor grade and stage in Qatari women with breast cancer.
المؤلف | Gupta, Ishita |
المؤلف | Jabeen, Ayesha |
المؤلف | Al-Sarraf, Reem |
المؤلف | Farghaly, Hanan |
المؤلف | Vranic, Semir |
المؤلف | Sultan, Ali A |
المؤلف | Al Moustafa, Ala-Eddin |
المؤلف | Al-Thawadi, Hamda |
تاريخ الإتاحة | 2020-10-05T04:48:24Z |
تاريخ النشر | 2020-10-02 |
اسم المنشور | Human Vaccines and Immunotherapeutics |
المعرّف | http://dx.doi.org/10.1080/21645515.2020.1802977 |
الاقتباس | Ishita Gupta, Ayesha Jabeen, Reem Al-Sarraf, Hanan Farghaly, Semir Vranic, Ali A. Sultan, Ala-Eddin Al Moustafa & Hamda Al-Thawadi (2020) The co-presence of high-risk human papillomaviruses and Epstein-Barr virus is linked with tumor grade and stage in Qatari women with breast cancer, Human Vaccines & Immunotherapeutics, DOI: 10.1080/21645515.2020.1802977 |
الرقم المعياري الدولي للكتاب | 2164-5515 |
الملخص | High-risk human papillomaviruses (HPV) can be present and cooperate with Epstein-Barr virus (EBV) to promote the onset and/or progression of various cancers including cervical, breast, head and neck as well as colorectal. In this investigation, we explored the co-prevalence of high-risk HPV and EBV in 74 breast cancer tissues from Qatari women using polymerase chain reaction. We found that high-risk HPV and EBV are present in 48/74 (65%) and 36/74 (49%) of the cases, respectively. While we noted that the presence of HPV presence is associated with triple-negative breast cancer (TNBC) ( = .008), however, the presence of EBV did not correlate with any breast cancer subgroup. Moreover, our data revealed that high-risk HPV and EBV are co-present in 35/74 (47%) of the samples and their co-presence is significantly associated with tumor grade ( = .04) and tumor stage ( = .04). These data indicate that HPV and EBV are commonly co-present in breast cancer and their association could be linked with a more aggressive tumor phenotype. Thus, further investigations are essential to understand the underlying mechanisms of HPV and EBV cooperation in breast carcinogenesis. |
راعي المشروع | grants from Qatar University [QUCG-CMED-2018/2019-3, QUHI-CMED-19/20-1 and QUCG-CMED-20/21-2 |
اللغة | en |
الناشر | Taylor and Francis |
الموضوع | EBV HPV Qatari population breast cancer tumor grade tumor stage |
النوع | Article |
الصفحات | 1-8 |
ESSN | 2164-554X |
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