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AuthorSiddiqui, Maheen
AuthorManansala, Judhell S
AuthorAbdulrahman, Hana A
AuthorNasrallah, Gheyath K
AuthorSmatti, Maria K
AuthorYounes, Nadin
AuthorAlthani, Asmaa A
AuthorYassine, Hadi M
Available date2020-11-09T05:55:42Z
Publication Date2020-09-01
Publication NameNutrients
Identifierhttp://dx.doi.org/10.3390/nu12092879
CitationSiddiqui M, Manansala JS, Abdulrahman HA, Nasrallah GK, Smatti MK, Younes N, Althani AA, Yassine HM. Immune Modulatory Effects of Vitamin D on Viral Infections. Nutrients. 2020 Sep 21;12(9):2879. doi: 10.3390/nu12092879. PMID: 32967126; PMCID: PMC7551809.
URIhttp://hdl.handle.net/10576/16953
AbstractViral infections have been a cause of mortality for several centuries and continue to endanger the lives of many, specifically of the younger population. Vitamin D has long been recognized as a crucial element to the skeletal system in the human body. Recent evidence has indicated that vitamin D also plays an essential role in the immune response against viral infections and suggested that vitamin D deficiency increases susceptibility to viral infections as well as the risk of recurrent infections. For instance, low serum vitamin D levels were linked to increased occurrence of high burdens viral diseases such as hepatitis, influenza, Covid-19, and AIDS. As immune cells in infected patients are responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing vitamin D-deficient individuals with an infectious disease may extend beyond the impact on bone and calcium homeostasis. Even though numerous studies have highlighted the effect of vitamin D on the immune cells, vitamin D's antiviral mechanism has not been fully established. This paper reviews the recent mechanisms by which vitamin D regulates the immune system, both innate and adaptive systems, and reflects on the link between serum vitamin D levels and viral infections.
Languageen
PublisherMDPI
SubjectAIDS
Covid-19
Influenza
deficiency
hepatitis
vitamin D
TitleImmune Modulatory Effects of Vitamin D on Viral Infections.
TypeArticle
Issue Number9
Volume Number12
ESSN2072-6643
dc.accessType Open Access


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