Show simple item record

AuthorFarhan, Cyprian
AuthorSohail, Muhammad Umar
AuthorAbdelhafez, Ibrahim
AuthorSalman, Salma
AuthorAttique, Zakria
AuthorKamareddine, Layla
AuthorAl-Asmakh, Maha
Available date2021-03-25T06:35:51Z
Publication Date2021-04-30
Publication NameInternational Journal of Infectious Diseases
Identifierhttp://dx.doi.org/10.1016/j.ijid.2021.02.071
CitationCyprian F, Sohail MU, Abdelhafez I, Salman S, Attique Z, Kamareddine L, Al-Asmakh M. SARS-CoV-2-Immune-Microbiome Interaction: Lessons from Respiratory Viral Infections. Int J Infect Dis. 2021 Feb 18;105:540–50. doi: 10.1016/j.ijid.2021.02.071.
ISSN12019712
URIhttps://www.sciencedirect.com/science/article/pii/S1201971221001569
URIhttp://hdl.handle.net/10576/17970
AbstractBy the beginning of 2020, infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had rapidly evolved into an emergent worldwide pandemic, an outbreak whose unprecedented consequences highlighted many existing flaws within public healthcare systems across the world. While coronavirus disease 2019 (COVID-19) is bestowed with a broad spectrum of clinical manifestations, involving the vital organs, the respiratory system transpires as the main route of entry for SARS-CoV-2, with the lungs being its primary target. Of those infected, up to 20% require hospitalization on account of severity, while the majority of patients are either asymptomatic or exhibit mild symptoms. Exacerbation in the disease severity and complications of COVID-19 infection have been associated with multiple comorbidities, including hypertension, diabetes mellitus, cardiovascular disorders, cancer, and chronic lung disease. Interestingly, a recent body of evidence indicated the pulmonary and gut microbiomes as potential modulators for altering the course of COVID-19, potentially via the microbiome-immune system axis. While the relative concordance between microbes and immunity has yet to be fully elucidated with regards to COVID-19, we present an overview of our current understanding of COVID-19-microbiome-immune cross talk and discuss the potential contributions of microbiome-related immunity to SARS-CoV-2 pathogenesis and COVID-19 disease progression.
Languageen
PublisherElsevier
SubjectSARS-CoV-2
SubjectCOVID-19
SubjectRespiratory tract microbiome
SubjectGut microbiome
SubjectImmunity
TitleSARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections
TypeArticle
Pagination540-550
Volume Number105
Open Access user License http://creativecommons.org/licenses/by-nc-nd/4.0/


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record