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AuthorNeoh, Chin Fen
AuthorLeung, Lok
AuthorChan, Elsie
AuthorAl-Badriyeh, Daoud
AuthorFullinfaw, Robert O.
AuthorJhanji, Vishal
AuthorVajpayee, Rasik B.
AuthorDavies, Geoffrey E.
AuthorStewart, Kay
AuthorKong, David C. M.
Available date2021-04-22T13:00:31Z
Publication Date2016
Publication NameAntimicrobial Agents and Chemotherapy
ResourceScopus
URIhttp://dx.doi.org/10.1128/AAC.00683-16
URIhttp://hdl.handle.net/10576/18345
AbstractTwenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis.
Languageen
PublisherAmerican Society for Microbiology
Subjecteye drops
Subjectvoriconazole
Subjectantifungal agent
Subjecteye drops
Subjectvoriconazole
Subjectadult
Subjectaged
Subjectaqueous humor
SubjectArticle
Subjectcataract extraction
Subjectclinical article
Subjectdrug absorption
Subjectdrug clearance
Subjectdrug elimination
Subjectdrug half life
Subjectelective surgery
Subjectelimination half-life
Subjectelimination rate constant
Subjectfemale
Subjecthigh performance liquid chromatography
Subjecthuman
Subjectin vitro study
Subjectinfection prevention
Subjectkeratomycosis
Subjectmale
Subjectmiddle aged
Subjectminimum inhibitory concentration
Subjectopen study
Subjectparacentesis
Subjectpostoperative infection
Subjectpriority journal
Subjectvery elderly
Subjectclinical trial
Subjectdrug effects
SubjectAdult
SubjectAged
SubjectAged, 80 and over
SubjectAntifungal Agents
SubjectAqueous Humor
SubjectCataract Extraction
SubjectFemale
SubjectHumans
SubjectMale
SubjectMiddle Aged
SubjectOphthalmic Solutions
SubjectVoriconazole
TitleOpen-label study of absorption and clearance of 1% voriconazole eye drops
TypeArticle
Pagination6896-6898
Issue Number11
Volume Number60


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