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المؤلفLuis, Furuya-Kanamori
المؤلفXu, Chang
المؤلفDoi, Suhail A.R.
المؤلفClark, Justin
المؤلفWangdi, Kinley
المؤلفMills, Deborah J.
المؤلفLau, Colleen L.
تاريخ الإتاحة2021-07-11T10:14:29Z
تاريخ النشر2021-07-22
اسم المنشورVaccine
المعرّفhttp://dx.doi.org/10.1016/j.vaccine.2021.06.023
الاقتباسFuruya-Kanamori L, Xu C, Doi SAR, Clark J, Wangdi K, Mills DJ, Lau CL. Comparison of immunogenicity and safety of licensed Japanese encephalitis vaccines: A systematic review and network meta-analysis. Vaccine. 2021 Jun 23:S0264-410X(21)00759-3. doi: 10.1016/j.vaccine.2021.06.023.
الرقم المعياري الدولي للكتاب0264410X
معرّف المصادر الموحدhttp://hdl.handle.net/10576/21403
الملخصIntroductionAnnually more than 100,000 Japanese encephalitis (JE) cases and 25,000 deaths worldwide are caused by JE virus infection. More than 15 JE vaccines are currently in use worldwide. It is unknown whether any of the vaccines is superior to the others in terms of immunogenicity and safety. MethodsFour databases were systematically searched for randomised controlled trials that compared two or more types of JE vaccines. Vaccines were classified into four classes: inactivated mouse brain-derived (oldest class), inactivated Vero cell, live chimeric, and live attenuated. Network meta-analysis was used to generate mixed effect estimates against inactivated mouse brain-derived vaccines for seroconversion, and against placebo for adverse event (AE) and severe adverse event (SAE). Results23 studies (38,496 participants) were included. All newer vaccine classes had better immunogenicity, the difference was statistically significant for inactivated Vero cell (OR = 2.98; 95 %CI: 1.02–8.65) and live chimeric (OR = 5.93; 95 %CI: 1.73–20.32) vaccines. Inactivated mouse-derived vaccines had the highest odds for AEs (OR = 2.27; 95 %CI: 1.59–3.23), the odds of AE of newer vaccines was not different to placebo. There was no difference in SAEs across vaccine classes. ConclusionsAll newer JE vaccines have comparable safety profiles, live chimeric and inactivated Vero cell vaccines are the most immunogenic among the newer vaccine classes.
اللغةen
الناشرElsevier
الموضوعJapanese encephalitis
Vaccination
Adverse events
Severe
Seroconversion
Efficacy
العنوانComparison of immunogenicity and safety of licensed Japanese encephalitis vaccines: A systematic review and network meta-analysis
النوعArticle Review
الصفحات4429-4436
رقم العدد32
رقم المجلد39
dc.accessType Full Text


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