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AuthorLuis, Furuya-Kanamori
AuthorXu, Chang
AuthorDoi, Suhail A.R.
AuthorClark, Justin
AuthorWangdi, Kinley
AuthorMills, Deborah J.
AuthorLau, Colleen L.
Available date2021-07-11T10:14:29Z
Publication Date2021-07-22
Publication NameVaccineen_US
Identifierhttp://dx.doi.org/10.1016/j.vaccine.2021.06.023
CitationFuruya-Kanamori L, Xu C, Doi SAR, Clark J, Wangdi K, Mills DJ, Lau CL. Comparison of immunogenicity and safety of licensed Japanese encephalitis vaccines: A systematic review and network meta-analysis. Vaccine. 2021 Jun 23:S0264-410X(21)00759-3. doi: 10.1016/j.vaccine.2021.06.023.
ISSN0264410X
URIhttp://hdl.handle.net/10576/21403
AbstractIntroductionAnnually more than 100,000 Japanese encephalitis (JE) cases and 25,000 deaths worldwide are caused by JE virus infection. More than 15 JE vaccines are currently in use worldwide. It is unknown whether any of the vaccines is superior to the others in terms of immunogenicity and safety. MethodsFour databases were systematically searched for randomised controlled trials that compared two or more types of JE vaccines. Vaccines were classified into four classes: inactivated mouse brain-derived (oldest class), inactivated Vero cell, live chimeric, and live attenuated. Network meta-analysis was used to generate mixed effect estimates against inactivated mouse brain-derived vaccines for seroconversion, and against placebo for adverse event (AE) and severe adverse event (SAE). Results23 studies (38,496 participants) were included. All newer vaccine classes had better immunogenicity, the difference was statistically significant for inactivated Vero cell (OR = 2.98; 95 %CI: 1.02–8.65) and live chimeric (OR = 5.93; 95 %CI: 1.73–20.32) vaccines. Inactivated mouse-derived vaccines had the highest odds for AEs (OR = 2.27; 95 %CI: 1.59–3.23), the odds of AE of newer vaccines was not different to placebo. There was no difference in SAEs across vaccine classes. ConclusionsAll newer JE vaccines have comparable safety profiles, live chimeric and inactivated Vero cell vaccines are the most immunogenic among the newer vaccine classes.
Languageen
PublisherElsevier
SubjectJapanese encephalitis
SubjectVaccination
SubjectAdverse events
SubjectSevere
SubjectSeroconversion
SubjectEfficacy
TitleComparison of immunogenicity and safety of licensed Japanese encephalitis vaccines: A systematic review and network meta-analysis
TypeArticle Review
Pagination4429-4436
Issue Number32
Volume Number39


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