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المؤلفNagi, Karim
المؤلفGupta, Ishita
المؤلفJurdi, Nawaf
المؤلفYasmeen, Amber
المؤلفVranić, Semir
المؤلفBatist, Gerald
المؤلفAl Moustafa, Ala-Eddin
تاريخ الإتاحة2021-08-05T08:52:50Z
تاريخ النشر2021-07-29
اسم المنشورInternational Journal of Molecular Sciences
المعرّفhttp://dx.doi.org/10.3390/ijms22158118
الاقتباسNagi, K.; Gupta, I.; Jurdi, N.; Yasmeen, A.; Vranic, S.; Batist, G.; Moustafa, A.-E.A. Copresence of High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer: A Tissue Microarray and Molecular Study from Lebanon. Int. J. Mol. Sci. 2021, 22, 8118. https://doi.org/10.3390/ijms22158118
الرقم المعياري الدولي للكتاب1661-6596
المعرّف8118
معرّف المصادر الموحدhttp://hdl.handle.net/10576/21627
الملخصColorectal cancer (CRC) is the third most common cause of cancer-related deaths worldwide. Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV) have been reported to be present in different types of human cancers including CRC where they can play a key role in the onset and/or progression of these cancers. Thus, we herein explored the prevalence of high-risk HPVs and EBV in a cohort of 94 CRC tissue samples and 13 colorectal normal tissues from the Lebanese population using polymerase chain reaction, immunohistochemistry, and tissue microarray methodologies. We found that high-risk HPVs are present in 64%, while EBV is present in 29% of our CRC samples. Additionally, our data showed that high-risk HPV types (16, 18, 35, 58, 51, 45, 52, 31 and 33) are the most frequent in CRC in the Lebanese cohort, respectively. Our data point out that HPVs and EBV are co-present in 28% of the samples. Thus, this study clearly suggests that high-risk HPVs and EBV are present/co-present in CRCs where they could play an important role in colorectal carcinogenesis. Nevertheless, further investigations in a larger cohort are needed to elucidate the possible cooperation between these oncoviruses in the development of CRC.
راعي المشروعThis research was funded by grants from Qatar University: QUHI-CMED-19/20-1 and QUCG-CMED-20/21-2
اللغةen
الناشرMDPI
الموضوعEpstein–Barr virus
human papillomavirus
colorectal cancer
tumor grade
Lebanon
العنوانCopresence of High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer: A Tissue Microarray and Molecular Study from Lebanon
النوعArticle
رقم العدد15
رقم المجلد22
ESSN1422-0067
dc.accessType Open Access


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