Browsing Academic by Author "Zakaria, Zain Zaki"
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Design and Microinjection of Morpholino Antisense Oligonucleotides and mRNA into Zebrafish Embryos to Elucidate Specific Gene Function in Heart Development
Zakaria, Zain Zaki; Eisa-Beygi, Shahram; Benslimane, Fatiha; Ramchandran4, Ramani; Yalcin, Huseyin C. ( MyJove Corporation , 2022 , Article)The morpholino oligomer-based knockdown system has been used to identify the function of various gene products through loss or reduced expression. Morpholinos (MOs) have the advantage in biological stability over DNA oligos ... -
The effect of surface-modified gold nanorods on the early stage of embryonic development and angiogenesis: Insight into the molecular pathways
Mahmoud, Nouf N.; Zakaria, Zain Zaki; Kheraldine, Hadeel; Gupta, Ishita; Vranic, Semir; Al-Asmakh, Maha; Moustafa, Ala Eddin Al... more authors ... less authors ( MDPI , 2021 , Article)Gold nanorods have been implicated in several biomedical applications. Herein, the effect of two surface-modified gold nanorods on the early stages of embryogenesis and angiogenesis was investigated using avian embryos at ... -
Effect of Water-Pipe Smoking on the Normal Development of Zebrafish
Zakaria, Zain Zaki; Aladwi, Shaima Ahmad; Benslimane, Fatiha; Al-Absi, Enas S.; Al-Shafai, Mashael; Yalcin, Huseyin C.; Khalil, Ashraf; Al Moustafa, Ala-Eddin; Al-Asmakh, Maha... more authors ... less authors ( MDPI , 2021 , Article)Background: Among all types of tobacco consumption,Water-Pipe Smoking (WPS) is the most widely used in the Middle East and second-most in several other countries. The effect of WPS on normal development is not yet fully ... -
The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review
Sokary, Sara; Bawadi, Hiba; Zakaria, Zain Zaki; Al-Asmakh, Maha ( Taylor & Francis , 2024 , Article)Spirulina (Arthrospira platensis) is a cyanobacterium associated with multiple health benefits. Cardiometabolic diseases such as cardiovascular disease, nonalcoholic fatty liver disease, and diabetes are prevalent yet ... -
Metagenomic Analysis of Oral Microbiome during pregnancy
Farah, Huda Mohamed; Elamin, Muram Elmubarak; Nader, Rahaf Nader Nader; Alabsi, Rana Said; Bouabidi, Salma Bouazza; Suleiman, Sara Elgaili Khogali; Nasr, Shahd Mohammad; Al-Rumaihi, Shouq Fahad; Zakaria, Zain Zaki; Alasmakh, Maha alasmakh... more authors ... less authors ( Qatar University Press , 2021 , Poster)Pregnancy is a dynamic physiological process associated with significant hormonal, immune and metabolic changes to support the growth and development of the fetus. Several studies have highlighted the role of gut microbiota ... -
Physiological Changes and Interactions Between Microbiome and the Host During Pregnancy
Zakaria, Zain Zaki; Al-Rumaihi, Shouq; Al-Absi, Rana; Farah, Huda; Elamin, Muram; Nader, Rahaf; Bouabidi, Salma; Suleiman, Sara Elgaili; Nasr, Shahd; Al-Asmakh, Maha... more authors ... less authors ( Frontiers Media , 2022 , Article Review)In recent years, it has become clear that microbiome play a variety of essential roles in human metabolism, immunity, and overall health and that the composition of these microbiome is influenced by our environment, diet, ... -
Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model.
Al-Thani, Hissa F; Shurbaji, Samar; Zakaria, Zain Zaki; Hasan, Maram H; Goracinova, Katerina; Korashy, Hesham M; Yalcin, Huseyin C... more authors ... less authors ( MDPI , 2022 , Article)Tyrosine kinase inhibitors (TKIs) are the new generation of anti-cancer drugs with high potential against cancer cells' proliferation and growth. However, TKIs are associated with severe cardiotoxicity, limiting their ... -
Toxicity assessment of treated sewage effluent using the zebrafish embryo model
Nasser, Fatima Abdulwahab; Nasir, Halah Noor; Zakaria, Zain Zaki; Yalcin, Huseyin ( Qatar University Press , 2020 , Poster)Background: In a context of tremendous economic value, the management and protection of water resources in Qatar has long been a significant issue as part of the global wastewater management plan. The process is based on ... -
Uncovering the Epigenetic Contribution of Protein Arginine Methyltransferase 5 (PRMT5) during Zebrafish Cardiomyogenesis
Zakaria, Zain Zaki (2020 , Dissertation)The heart develops through an extremely intricate process mediated by a network of transcription factors initiated by key chromatin modification events. Scientist have implicated the protein arginine methyltransferase ...