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    The effect of surface-modified gold nanorods on the early stage of embryonic development and angiogenesis: Insight into the molecular pathways

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    ijms-22-11036.pdf (2.696Mb)
    Date
    2021-10-01
    Author
    Mahmoud, Nouf N.
    Zakaria, Zain Zaki
    Kheraldine, Hadeel
    Gupta, Ishita
    Vranic, Semir
    Al-Asmakh, Maha
    Moustafa, Ala Eddin Al
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    Abstract
    Gold nanorods have been implicated in several biomedical applications. Herein, the effect of two surface-modified gold nanorods on the early stages of embryogenesis and angiogenesis was investigated using avian embryos at three days and their chorioallantoic membrane (CAM) at five days of incubation. We found that gold nanorods (GNR) modified with PEGylated phospholipid moiety show a high mortality rate in embryos after four days of exposure compared to GNR modified with PEGylated cholesterol moiety. Meanwhile, our data revealed that surface modified-GNR significantly inhibit the formation of new blood vessels in the treated CAM model after 48 h of exposure. Moreover, we report that surface-modified GNR significantly deregulate the expression of several genes implicated in cell proliferation, invasion, apoptosis, cellular energy metabolism, and angiogenesis. On the other hand, our data point out that GNR treatments can modulate the expression patterns of JNK1/2/3, NF-KB/p38, and MAPK, which could be the main molecular pathways of the nanorods in our experimental models.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85117002503&origin=inward
    DOI/handle
    http://dx.doi.org/10.3390/ijms222011036
    http://hdl.handle.net/10576/24692
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    • Biomedical Research Center Research [‎800‎ items ]
    • Biomedical Sciences [‎819‎ items ]
    • Medicine Research [‎1794‎ items ]

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