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Risk prediction of early decline in renal function in diabetic kidney disease with algorithm including fractional excretion of glycated amino acids

Rabbani, Naila; de a Fuente, Alberto; Thornalley, Paul ( Qatar University Press , 2021 , Poster)

Background and aims: Diabetic kidney disease occurs in ca. 40% patients with diabetes. Approximately 1 in 5 patients with type 1 diabetes mellitus (T1DM) and 1 in 3 patients with type 2 diabetes mellitus (T2DM) develop ...

Evaluation of antiviral activity of Manuka honey against SARS-CoV-2.

Elbashir, Israa; Aisha Nasser J M Al-Saei, Aisha; Thornalley, Paul; Rabbani, Naila ( Qatar University Press , 2021 , Poster)

Background and aims: In 2020 a global pandemic was declared caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). The pandemic is still ongoing and continues to cause considerable mortality and morbidity ...

Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome

Alhujaily, Muhanad; Abbas, Hafsa; Xue, Mingzhan; de la Fuente, Alberto; Rabbani, Naila; ... more authors ... less authors ( Frontiers Media S.A. , 2021 , Article)

Background: Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase ...

Methylglyoxal and glyoxalase 1-a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes

Rabbani, Naila ( Portland Press Ltd , 2022 , Article)

The study of the glyoxalase system by Thornalley and co-workers in clinical diabetes mellitus and correlation with diabetic complications revealed increased exposure of patients with diabetes to the reactive, dicarbonyl ...

Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer

Ashour, Amal; Xue, Mingzhan; Al-Motawa, Maryam; Thornalley, Paul J.; Rabbani, Naila ( BMJ Publishing Group , 2020 , Article)

Introduction Patients with diabetes have increased risk of periodontal disease, with increased risk of weakening of periodontal ligament and tooth loss. Periodontal ligament is produced and maintained by periodontal ligament ...

Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 Infection

Al-Motawa, Maryam S.; Abbas, Hafsa; Wijten, Patrick; de la Fuente, Alberto; Xue, Mingzhan; ... more authors ... less authors ( Frontiers Media , 2020 , Article)

The global pandemic of COVID-19 disease caused by infection with the SARS-CoV-2 coronavirus, has produced an urgent requirement and search for improved treatments while effective vaccines are developed. A strategy for ...

Antiviral activity of glucose-derived reactive metabolite, methylglyoxal against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

AlKhatib, Hebah A M; ElBashir, Israa; Yassine, Hadi M.; Thornalley, Paul J; Rabbani, Naila ( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)

Background: The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in a global health emergency. With incomplete vaccination and incomplete protection of the vaccinated population, there remains an urgent ...

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle

Jinit, Masania; Wijten, Patrick; Keipert, Susanne; Ost, Mario; Klaus, Susanne; ... more authors ... less authors ( Elsevier , 2023 , Article)

Mice with ectopic expression of uncoupling protein-1 (UCP1) in skeletal muscle exhibit a healthy aging phenotype with increased longevity and resistance to impaired metabolic health. This may be achieved by decreasing ...

Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis—Driver of Insulin Resistance and Development of Vascular Complications of Diabetes

Rabbani, Naila; Xue, Mingzhan; Thornalley, Paul J. ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)

The recent discovery of the glucose-induced stabilization of hexokinase-2 (HK2) to proteolysis in cell dysfunction in model hyperglycemia has revealed a likely key initiating factor contributing to the development of insulin ...

AGEomics Biomarkers and Machine Learning—Realizing the Potential of Protein Glycation in Clinical Diagnostics

Rabbani, Naila ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)

Protein damage by glycation, oxidation and nitration is a continuous process in the physiological system caused by reactive metabolites associated with dicarbonyl stress, oxidative stress and nitrative stress, respectively. ...