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Blood biomarkers associated with autism spectrum disorder may provide early diagnosis

Rabbani, Naila; Thornalley, Paul John ( Qatar University Press , 2020 , Poster)

Autism Spectrum Disorders (ASD) are a collection of neuropsychiatric disorders. ASD affects 1 in 87 in Qatar and is expected to increase. The high variability and heterogeneity of the symptoms makes diagnosis of ASD difficult ...

High fractional excretion of glycation adducts is associated with subsequent early decline in renal function in type 1 diabetes

Perkins, B.A.; Perkins, Bruce A.; Rabbani, Naila; Weston, Andrew; Adaikalakoteswari, Antonysunil; ... more authors ... less authors ( Nature Publishing Group , 2020 , Article)

Increased protein glycation, oxidation and nitration is linked to the development of diabetic nephropathy. We reported levels of serum protein glycation, oxidation and nitration and related hydrolysis products, glycation, ...

Vulnerabilities of the SARS-CoV-2 virus to proteotoxicity - opportunity for repurposed chemotherapy of COVID-19 infection

Rabbani, Naila; Thornalley, Paul John; Al-Motawa, Maryam; Xue, Mingzhan ( Qatar University Press , 2020 , Poster)

The global pandemic of COVID-19 disease caused by infection with the SARS-CoV-2 coronavirus, has produce an urgent requirement and search for improved treatments whilst effective vaccines are developed. A strategy for ...

Protein Glycation in Plants-An Under-Researched Field with Much Still to Discover.

Rabbani, Naila; Al-Motawa, Maryam; Thornalley, Paul J ( MDPI , 2020 , Article)

Recent research has identified glycation as a non-enzymatic post-translational modification of proteins in plants with a potential contributory role to the functional impairment of the plant proteome. Reducing sugars with ...

A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration.

Rowan, Sheldon; Jiang, Shuhong; Chang, Min-Lee; Volkin, Jonathan; Cassalman, Christa; ... more authors ... less authors ( Elsevier , 2020 , Article)

Age-related macular degeneration (AMD) is a major blinding disease, affecting over 14% of the elderly. Risk for AMD is related to age, diet, environment, and genetics. Dietary modulation of AMD risk is a promising treatment ...

Potential Markers of Dietary Glycemic Exposures for Sustained Dietary Interventions in Populations without Diabetes.

Feskens, Edith; Brennan, Lorraine; Dussort, Pierre; Flourakis, Matthieu; Lindner, Lena M E; ... more authors ... less authors ( Oxford University Press , 2020 , Article)

There is considerable interest in dietary and other approaches to maintaining blood glucose concentrations within the normal range and minimizing exposure to postprandial hyperglycemic excursions. The accepted marker to ...

Reading patterns of proteome damage by glycation, oxidation and nitration: quantitation by stable isotopic dilution analysis LC-MS/M

Rabbani, Naila; Thornalley, Paul J. ( Portland Press , 2020 , Article Review)

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) provides a high sensitivity, high specificity multiplexed method for concurrent detection of adducts formed by protein glycation, oxidation and nitration, also ...