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    Genomic insights and advanced machine learning: characterizing autism spectrum disorder biomarkers and genetic interactions 

    Nahas, Laila Dabab; Datta, Ankur; Alsamman, Alsamman M.; Adly, Monica H.; Al-Dewik, Nader; Sekaran, Karthik; Sasikumar, K.; Verma, Kanika; Doss, George Priya C.; Zayed, Hatem... more authors ... less authors ( Springer , 2024 , Article)
    Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by altered brain connectivity and function. In this study, we employed advanced bioinformatics and explainable AI to analyze gene ...
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    Rational design of a multivalent vaccine targeting arthropod-borne viruses using reverse vaccinology strategies 

    Dhanushkumar, T.; Selvam, Prasanna kumar; M E, Santhosh; Vasudevan, Karthick; C, George Priya Doss; Zayed, Hatem; Kamaraj, Balu... more authors ... less authors ( Elsevier , 2024 , Article)
    Viruses transmitted by arthropods, such as Dengue, Zika, and Chikungunya, represent substantial worldwide health threats, particularly in countries like India. The lack of approved vaccines and effective antiviral therapies ...
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    Identification of Potential Inhibitors Targeting GTPase-Kirsten RAt Sarcoma Virus (K-Ras) Driven Cancers via E-Pharmacophore-Based Virtual Screening and Drug Repurposing Approach 

    Kumar. S, Udhaya; Varghese, Rinku Polachirakkal; Preethi, V. Anu; Doss, C. George Priya; Zayed, Hatem ( IMR Press Limited , 2023 , Article)
    Background: Mutations in the K-Ras gene are among the most frequent genetic alterations in various cancers, and inhibiting RAS signaling has shown promising results in treating solid tumors. However, finding effective drugs ...
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    Bioinformatics investigation on blood-based gene expressions of Alzheimer's disease revealed ORAI2 gene biomarker susceptibility: An explainable artificial intelligence-based approach 

    Sekaran, Karthik; Alsamman, Alsamman M.; George Priya Doss, C.; Zayed, Hatem ( Springer , 2023 , Article)
    The progressive, chronic nature of Alzheimer's disease (AD), a form of dementia, defaces the adulthood of elderly individuals. The pathogenesis of the condition is primarily unascertained, turning the treatment efficacy ...
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    Airway and Oral microbiome profiling of SARS-CoV-2 infected asthma and non-asthma cases revealing alterations-A pulmonary microbial investigation 

    Sekaran, Karthik; Varghese, Rinku Polachirakkal; Doss C., George Priya; Alsamman, Alsamman M.; Zayed, Hatem; El Allali, Achraf... more authors ... less authors ( NLM (Medline) , 2023 , Article)
    New evidence strongly discloses the pathogenesis of host-associated microbiomes in respiratory diseases. The microbiome dysbiosis modulates the lung's behavior and deteriorates the respiratory system's effective functioning. ...
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    Potential Therapeutic Targets of Resveratrol in the Prevention and Treatment of Pulmonary Fibrosis 

    Ramli, Iman; Cheriet, Thamere; Posadino, Anna Maria; Giordo, Roberta; Zayed, Hatem; Eid, Ali H.; Pintus, Gianfranco... more authors ... less authors ( IMR Press Limited , 2023 , Article)
    Pulmonary fibrosis (PF) is a feared component in over 200 interstitial pulmonary diseases, which are characterized by increased alveolar wall thickness, excessive scarring, and aberrant extracellular matrix restructuring ...

    Single-cell transcriptomic analysis reveals crucial oncogenic signatures and its associative cell types involved in gastric cancer 

    Sekaran, Karthik; Varghese, Rinku Polachirakkal; Zayed, Hatem; El Allali, Achraf; George Priya Doss, C. ( Springer Nature , 2023 , Article)
    The intricate association of oncogenic markers negatively impacts accurate gastric cancer diagnosis and leads to the proliferation of mortality rate. Molecular heterogeneity is inevitable in determining gastric cancer's ...
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    Dissecting Crucial Gene Markers Involved in HPV-Associated Oropharyngeal Squamous Cell Carcinoma from RNA-Sequencing Data through Explainable Artificial Intelligence 

    Sekaran, Karthik; Varghese, Rinku Polachirakkal; Krishnan, Sasikumar; Zayed, Hatem; El Allali, Achraf; Doss, George Priya C... more authors ... less authors ( IMR Press Limited , 2024 , Article)
    Background: The incidence rate of oropharyngeal squamous cell carcinoma (OPSCC) worldwide is alarming. In the clinical community, there is a pressing necessity to comprehend the etiology of the OPSCC to facilitate the ...
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    Bladder neoplasms and NF-κB: an unfathomed association. 

    Jebaraj Walter, Charles Emmanuel; Durairajan, Sankari; Periyandavan, Kalaiselvi; Priya Doss C, George; Davis G, Dicky John; Vasanthi A, Hannah Rachel; Johnson, Thanka; Zayed, Hatem... more authors ... less authors ( Taylor & Francis , 2020 , Article)
    Bladder cancer is the second most common genitourinary tract cancer and is often recurrent and/or chemoresistant after tumor resection. Cigarette smoking, exposure to aromatic amines, and chronic infection/inflammation are ...
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    A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation causing breast cancer. 

    Thirumal Kumar, D; Jain, Nikita; Evangeline, Judith; Kamaraj, Balu; Siva, R; Zayed, Hatem; George Priya Doss, C... more authors ... less authors ( Elsevier , 2019 , Article)
    Breast cancer (BC) is the most commonly diagnosed cancer among females worldwide, and among the BC-associated mutations in various proteins, mutations in the RAC-alpha serine/threonine-protein kinase (AKT1) remain the most ...
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