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AuthorJeyaraj, Murugaraj
AuthorPraphakar, Rajendran Amarnath
AuthorRajendran, Chinnusamy
AuthorPonnamma, Deepalekshmi
AuthorSadasivuni, Kishor Kumar
AuthorMunusamy, Murugan A.
AuthorRajan, Mariappan
Available date2021-09-07T06:16:22Z
Publication Date2016
Publication NameRSC Advances
ResourceScopus
ISSN20462069
URIhttp://dx.doi.org/10.1039/c6ra01866a
URIhttp://hdl.handle.net/10576/22837
AbstractLignin (LIG), one of the major natural polymers in the biomass is widely used for various industrial and biomedical applications, mainly in its modified form of grafted lignin. The present study focuses on the isolation of lignin from Aloe barbadensis Miller by a microwave extraction technique and its applicability as a medicinal biomass. The isolated lignin was used for the synthesis of a drug carrier by grafting with methacrylate (MA). Lignin grafted methacrylate was synthesised (LIG-g-MA) via atom transfer radical polymerization (ATRP). 5-Fluorouracil (5-FU) was used as a model cancer drug and it was encapsulated on the hollow nanocarrier by the emulsion/solvent evaporation technique. While NMR spectroscopy elucidates the structure of the isolated lignin, FT-IR and XRD techniques address the binding nature and crystalline character of 5-FU loaded carrier. The surface morphology of the isolated lignin, grafted lignin and drug-loaded carrier was confirmed with SEM and TEM techniques. The encapsulation efficiency and in vitro drug release were studied to determine the efficiency of the carrier. The cell viability and cytotoxicity effect of 5-FU loaded on LIG-g-MA and unloaded LIG-g-MA were performed against MCF-7 and VERO cell lines. In short, the modified natural lignin based on LIG-g-MA hollow-nanofibrous material has been shown to be a potentially useful biocompatible nanocarrier in chemotherapy for cancer treatment. The Royal Society of Chemistry 2016.
Languageen
PublisherRoyal Society of Chemistry
SubjectKraft Lignin
Lignosulfuric Acid
Pulping
TitleSurface functionalization of natural lignin isolated from: Aloe barbadensis Miller biomass by atom transfer radical polymerization for enhanced anticancer efficacy
TypeArticle
Pagination51310-51319
Issue Number56
Volume Number6
dc.accessType Abstract Only


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