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    Is curcumin at the threshold of therapeutic effectiveness on patients with colon cancer? – A systematic review

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    Date
    2021
    Author
    Shafei, Laila Khaled
    Izham, Mohamed
    Billa, Nashiru
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    Abstract
    Curcumin, obtained from Curcuma longa, has been the subject of decades of scientific investigation on its therapeutic usefulness. It is reported to possess several therapeutic properties, of which anti-colon cancer is of interest in this review. Clinically, however, curcumin has yet to firm up its place among established anti-colon cancer therapeutic contenders. We aimed to systematically review the prevailing clinical evidence on the role of curcumin in colon cancer treatment. The review drawing from literature on clinical studies indicates fairly long-term tolerability. No regression of tumor was reported when curcumin was the sole intervention. An increase in p53 level expression was reported in a placebo-controlled study but no reduction in PGE2 or 5HETE. Pharmacokinetic data on healthy humans indicate that formulated curcumin delivery systems present significantly higher systemic bioavailability. It appears therefore that the clinical use of curcumin can potentially be realized only through appropriate formulation interventions
    URI
    https://doi.org/10.29117/quarfe.2021.0118
    DOI/handle
    http://hdl.handle.net/10576/24403
    Collections
    • Pharmacy Research [‎857‎ items ]
    • Theme 2: Health and Biomedical Sciences [‎80‎ items ]

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