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المؤلفWehbe, Zena
المؤلفHammoud, Safaa Hisham
المؤلفYassine, Hadi M
المؤلفFardoun, Manal
المؤلفEl-Yazbi, Ahmed F
المؤلفEid, Ali H
تاريخ الإتاحة2021-11-30T11:40:34Z
تاريخ النشر2021-07-05
اسم المنشورFrontiers in Immunology
المعرّفhttp://dx.doi.org/10.3389/fimmu.2021.659339
الاقتباسWehbe Z, Hammoud SH, Yassine HM, Fardoun M, El-Yazbi AF and Eid AH (2021) Molecular and Biological Mechanisms Underlying Gender Differences in COVID-19 Severity and Mortality. Front. Immunol. 12:659339. doi: 10.3389/fimmu.2021.659339
المعرّف659339
معرّف المصادر الموحدhttp://hdl.handle.net/10576/25283
الملخصGlobally, over two million people have perished due to the recent pandemic caused by SARS-CoV-2. The available epidemiological global data for SARS-CoV-2 portrays a higher rate of severity and mortality in males. Analyzing gender differences in the host mechanisms involved in SARS-CoV-2 infection and progression may offer insight into the more detrimental disease prognosis and clinical outcome in males. Therefore, we outline sexual dimorphisms which exist in particular host factors and elaborate on how they may contribute to the pronounced severity in male COVID-19 patients. This includes disparities detected in comorbidities, the ACE2 receptor, renin-angiotensin system (RAS), signaling molecules involved in SARS-CoV-2 replication, proteases which prime viral S protein, the immune response, and behavioral considerations. Moreover, we discuss sexual disparities associated with other viruses and a possible gender-dependent response to SARS-CoV-2 vaccines. By specifically highlighting these immune-endocrine processes as well as behavioral factors that differentially exist between the genders, we aim to offer a better understanding in the variations of SARS-CoV-2 pathogenicity.
اللغةen
الناشرFrontiers Media
الموضوعACE-2
COVID-19
SARS-CoV-2
gender difference
vaccine
العنوانMolecular and Biological Mechanisms Underlying Gender Differences in COVID-19 Severity and Mortality
النوعArticle
رقم المجلد12
dc.accessType Open Access


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