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    Blue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells

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    Main Article (1.754Mb)
    Date
    2021-04-01
    Author
    Zupin, L.
    Zupin, Luisa
    Gratton, Rossella
    Fontana, Francesco
    Clemente, Libera
    Pascolo, Lorella
    Ruscio, Maurizio
    Crovella, Sergio
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    Abstract
    The study of any intervention able to counteract SARS-CoV-2 pandemic is considerably envisaged. It was previously shown, in in vitro models of infections, that the LED blue light is able to decrease the viral load of HSV-1 and ZIKV. In our study, LED photobiomodulation therapy (PBMT) at blue wavelengths (450, 454 and 470 nm) was tested in an in vitro model of SARS-CoV-2 infection, employing three experimental settings: SARS-CoV-2 was irradiated and then transferred to cells; already infected cells were irradiated; cells were irradiated prior to infection. A decrement of the viral load was observed when previously infected cells were irradiated with all three tested wavelengths and relevant effects were registered especially at 48 hours post-infection, possibly suggesting that the blue light could interfere with the intracellular viral replication machinery. Our in vitro findings could represent the starting point for translational applications of PBMT as a supportive approach to fight SARS-CoV-2.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85101809002&origin=inward
    DOI/handle
    http://dx.doi.org/10.1002/jbio.202000496
    http://hdl.handle.net/10576/25805
    Collections
    • Biological & Environmental Sciences [‎931‎ items ]
    • COVID-19 Research [‎848‎ items ]

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