Blue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells
المؤلف | Zupin, L. |
المؤلف | Zupin, Luisa |
المؤلف | Gratton, Rossella |
المؤلف | Fontana, Francesco |
المؤلف | Clemente, Libera |
المؤلف | Pascolo, Lorella |
المؤلف | Ruscio, Maurizio |
المؤلف | Crovella, Sergio |
تاريخ الإتاحة | 2022-01-24T05:24:41Z |
تاريخ النشر | 2021-04-01 |
اسم المنشور | Journal of Biophotonics |
المعرّف | http://dx.doi.org/10.1002/jbio.202000496 |
الاقتباس | Zupin, L, Gratton, R, Fontana, F, et al. Blue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells. J. Biophotonics. 2021; 14:e202000496. https://doi.org/10.1002/jbio.202000496 |
الرقم المعياري الدولي للكتاب | 1864063X |
الملخص | The study of any intervention able to counteract SARS-CoV-2 pandemic is considerably envisaged. It was previously shown, in in vitro models of infections, that the LED blue light is able to decrease the viral load of HSV-1 and ZIKV. In our study, LED photobiomodulation therapy (PBMT) at blue wavelengths (450, 454 and 470 nm) was tested in an in vitro model of SARS-CoV-2 infection, employing three experimental settings: SARS-CoV-2 was irradiated and then transferred to cells; already infected cells were irradiated; cells were irradiated prior to infection. A decrement of the viral load was observed when previously infected cells were irradiated with all three tested wavelengths and relevant effects were registered especially at 48 hours post-infection, possibly suggesting that the blue light could interfere with the intracellular viral replication machinery. Our in vitro findings could represent the starting point for translational applications of PBMT as a supportive approach to fight SARS-CoV-2. |
اللغة | en |
الناشر | Wiley |
الموضوع | blue LED photobiomodulation therapy SARS-CoV-2 Vero E6 cell line |
النوع | Other |
رقم العدد | 4 |
رقم المجلد | 14 |
ESSN | 1864-0648 |
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