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    SARS-CoV-2 Short-Time Infection Produces Relevant Cytopathic Effects in Vero E6 Cell Line.

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    Date
    2021-08-26
    Author
    Zupin, Luisa
    Fontana, Francesco
    Gratton, Rossella
    Milani, Margherita
    Clemente, Libera
    Pascolo, Lorella
    Ruscio, Maurizio
    Crovella, Sergio
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    Abstract
    Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is mainly transmitted through respiratory droplets from positive subjects to susceptible hosts or by direct contact with an infected individual. Our study focuses on the in vitro minimal time of viral absorption as well as the minimal quantity of virus able to establish a persistent infection in Vero E6 cells. We observed that 1 min of in vitro virus exposure is sufficient to generate a cytopathic effect in cells after 7 days of infection, even at a multiplicity of infection (MOI) value of 0.01. Being aware that our findings have been obtained using an in vitro cellular model, we demonstrated that short-time exposures and low viral concentrations are able to cause infection, thus opening questions about the risk of SARS-CoV-2 transmissibility even following short contact times.
    DOI/handle
    http://dx.doi.org/10.3390/ijerph18179020
    http://hdl.handle.net/10576/25907
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    • Biological & Environmental Sciences [‎697‎ items ]
    • COVID-19 Research [‎465‎ items ]

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