Molecular Evidence of Anticancer Activity of Camel Milk Combined with Camel Urine
Author | Gupta, Ishita |
Author | Shanmuganathan, Sumaya |
Author | Al-Abri, Hisham |
Author | Ouhtit, Allal |
Available date | 2022-03-13T07:20:24Z |
Publication Date | 2021-08-10 |
Publication Name | Austin Journal of Cancer and Clinical Research |
Identifier | http://dx.doi.org/10.26420/austinjcancerclinres.2021.1093 |
Citation | Gupta I, Shanmuganathan S, Al-Abri H and Ouhtit A. Molecular Evidence of Anticancer Activity of Camel Milk Combined with Camel Urine. Austin J Cancer Clin Res. 2021; 8(2): 1093. |
Abstract | Camel Milk (CM) and Camel Urine (CU) is a traditional practice in the Middle East and other countries as an alternative treatment against cancer. We hypothesized that a combination of CM and CU (CM+CU), used at bioavailable concentrations, will result in cancer cell apoptosis without toxic effect on normal epithelial cell lines. Pursuant to this goal, we investigated CM+CU effect on breast (BC) and Prostate Cancer (PC) cell lines and examined its underlying mechanisms of action in-vitro. The highly metastatic BC (MDA-MB-231) and PC (PC3) cells as well as the non-tumorigenic epithelial cell line (MCF-10A) were treated with Filtered Camel Milk (FCM) and Virgin Camel Urine (VCU), both individually and in combination at bioavailable concentration levels. Although FCM and VCU were effective individually, the FCM+VCU combination significantly suppressed BC and PC cell proliferation (>80%), and surprisingly induced 100% cell death. In contrast, no deleterious effects were observed in MCF-10A control cells. More interestingly, the FCM+VCU combination upregulated Bax and downregulated expression of Bcl-2 and hypo-phosphorylated Rb expression in both BC and PC cell lines. In conclusion, this is the first study providing evidence of in-vitro chemo-preventive synergistic effect of FCM+VCU combination against BC and PC cells, supporting its anticancer property. |
Sponsor | This research was funded by Qatar University Internal grant number: QUST-1-CAS2019-22. |
Language | en |
Publisher | Austin Publishing Group |
Subject | Camel milk Camel urine Breast cancer Prostate cancer Cell proliferation Apoptosis |
Type | Article |
Issue Number | 2 |
Volume Number | 8 |
ESSN | 2381-909X |
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