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AuthorGupta, Ishita
AuthorShanmuganathan, Sumaya
AuthorAl-Abri, Hisham
AuthorOuhtit, Allal
Available date2022-03-13T07:20:24Z
Publication Date2021-08-10
Publication NameAustin Journal of Cancer and Clinical Research
Identifierhttp://dx.doi.org/10.26420/austinjcancerclinres.2021.1093
CitationGupta I, Shanmuganathan S, Al-Abri H and Ouhtit A. Molecular Evidence of Anticancer Activity of Camel Milk Combined with Camel Urine. Austin J Cancer Clin Res. 2021; 8(2): 1093.
URIhttp://hdl.handle.net/10576/27994
AbstractCamel Milk (CM) and Camel Urine (CU) is a traditional practice in the Middle East and other countries as an alternative treatment against cancer. We hypothesized that a combination of CM and CU (CM+CU), used at bioavailable concentrations, will result in cancer cell apoptosis without toxic effect on normal epithelial cell lines. Pursuant to this goal, we investigated CM+CU effect on breast (BC) and Prostate Cancer (PC) cell lines and examined its underlying mechanisms of action in-vitro. The highly metastatic BC (MDA-MB-231) and PC (PC3) cells as well as the non-tumorigenic epithelial cell line (MCF-10A) were treated with Filtered Camel Milk (FCM) and Virgin Camel Urine (VCU), both individually and in combination at bioavailable concentration levels. Although FCM and VCU were effective individually, the FCM+VCU combination significantly suppressed BC and PC cell proliferation (>80%), and surprisingly induced 100% cell death. In contrast, no deleterious effects were observed in MCF-10A control cells. More interestingly, the FCM+VCU combination upregulated Bax and downregulated expression of Bcl-2 and hypo-phosphorylated Rb expression in both BC and PC cell lines. In conclusion, this is the first study providing evidence of in-vitro chemo-preventive synergistic effect of FCM+VCU combination against BC and PC cells, supporting its anticancer property.
SponsorThis research was funded by Qatar University Internal grant number: QUST-1-CAS2019-22.
Languageen
PublisherAustin Publishing Group
SubjectCamel milk
Camel urine
Breast cancer
Prostate cancer
Cell proliferation
Apoptosis
TitleMolecular Evidence of Anticancer Activity of Camel Milk Combined with Camel Urine
TypeArticle
Issue Number2
Volume Number8
ESSN2381-909X
dc.accessType Open Access


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