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AuthorShabil Sha, Mizaj
AuthorMaurya, Muni Raj
AuthorShafath, Sadiyah
AuthorCabibihan, John-John
AuthorAl-Ali, Abdulaziz
AuthorMalik, Rayaz A.
AuthorSadasivuni, Kishor Kumar
Available date2022-03-23T06:35:42Z
Publication Date2022
Publication NameACS Omega
ResourceScopus
Identifierhttp://dx.doi.org/10.1021/acsomega.1c05948
CitationCS Omega 2022, 7, 5, 4257-4266 Publication Date:January 24, 2022 , https://doi.org/10.1021/acsomega.1c05948
URIhttp://hdl.handle.net/10576/28533
AbstractHuman breath analysis of volatile organic compounds has gained significant attention recently because of its rapid and noninvasive potential to detect various metabolic diseases. The detection of ketones in the breath and blood is key to diagnosing and managing diabetic ketoacidosis (DKA) in patients with type 1 diabetes. It may also be of increasing importance to detect euglycemic ketoacidosis in patients with type 1 or type 2 diabetes or heart failure, treated with sodium-glucose transporter-2 inhibitors (SGLT2-i). The present research evaluates the efficiency of colorimetry for detecting acetone and ethanol in exhaled human breath with the response time, pH effect, temperature effect, concentration effect, and selectivity of dyes. Using the proposed multidye system, we obtained a detection limit of 0.0217 ppm for acetone and 0.029 ppm for ethanol in the detection range of 0.05-50 ppm. A smartphone-assisted unit consisting of a portable colorimetric device was used to detect relative red/green/blue values within 60 s of the interface for practical and real-time application. The developed method could be used for rapid, low-cost detection of ketones in patients with type 1 diabetes and DKA and patients with type 1 or type 2 diabetes or heart failure treated with SGLT2-I and euglycemic ketoacidosis.
SponsorThis work was supported by the Qatar National Research Fund under NPRP11S-0110-180247. The statements made herein are solely the responsibility of the authors.
Languageen
PublisherAmerican Chemical Society
SubjectBreath Analysis
Vivo
Diabetic Ketoacidosis
TitleBreath Analysis for the in Vivo Detection of Diabetic Ketoacidosis
TypeArticle
Pagination4257-4266
Issue Number5
Volume Number7
dc.accessType Open Access


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