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    HER2-positive apocrine carcinoma of the breast: a population-based analysis of treatment and outcome.

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    s10549-022-06578-4.pdf (1.040Mb)
    Date
    2022-03-30
    Author
    Skenderi, Faruk
    Alahmad, Mohamad Alhoda Mohamad
    Tahirovic, Emin
    Alahmad, Yaman M
    Gatalica, Zoran
    Vranic, Semir
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    Abstract
    Apocrine carcinoma of the breast (APO) expresses HER2 in 30-50% of cases. This study explored the clinicopathological features and outcome of HER2+/APO and matched HER2+/NST cohort. We used the SEER database to explore the cohorts. Univariate and multivariate analyses were used to assess the survival. Based on ER and PR [steroid receptors/SR/] and HER2 status, we divided the cohorts to match the intrinsic molecular subtypes for comparisons. We retrieved 259 cases of HER2+/APO. Most HER2+/APO were SR negative (65%). HER2+/APO were more prevalent in the 80+ age group (24.7% vs. 15.7%, p < 0.001). HER2+/SR-/APO had a significantly lower histological grade than the HER2+/SR-/NST (p < 0.001). Breast cancer-related deaths were more prevalent in HER2+/NST (7.8% vs. 3.9%, p = 0.019). This was particularly evident between SR- subgroups (10.4% in HER2+/SR-/NST vs. 4.2% in HER2+/SR-/APO, p = 0.008) and was reaffirmed in breast cancer-specific survival in univariate analysis (p = 0.03). Other than race and SR status, HER2+/APO subgroups did not differ in clinicopathological parameters. Our study confirms the rarity of the APO and reveals that SR status in APO does not affect these patients' prognosis. HER2+/APO tumors tend to have a less aggressive phenotype and a more favorable outcome despite a markedly lower ER/PR positivity.
    DOI/handle
    http://dx.doi.org/10.1007/s10549-022-06578-4
    http://hdl.handle.net/10576/29274
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    • Medicine Research [‎1819‎ items ]

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