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المؤلفEltai, Nahla O.
المؤلفMahmoud, Nouf N.
المؤلفZakaria, Zain Z.
المؤلفAbdelrahman, Hana
المؤلفMoustafa, Ala Eddin Al
المؤلفAl-Asmakh, Maha
تاريخ الإتاحة2022-04-27T06:24:18Z
تاريخ النشر2022-01-01
اسم المنشورJournal of Inorganic and Organometallic Polymers and Materials
المعرّفhttp://dx.doi.org/10.1007/s10904-022-02294-0
الاقتباسEltai, N.O., Mahmoud, N.N., Zakaria, Z.Z. et al. Antibacterial and Antibiofilm Activity of Mercaptophenol Functionalized-Gold Nanorods Against a Clinical Isolate of Methicillin-Resistant Staphylococcus aureus. J Inorg Organomet Polym (2022). https://doi.org/10.1007/s10904-022-02294-0
الرقم المعياري الدولي للكتاب15741443
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85127691866&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/30686
الملخصGold nanorods (AuNRs) were synthesized by the seed-mediated wet chemical method using a binary surfactant system. AuNRs were stabilized with polyethylene glycol, then functionalized with 4-mercaptophenol (4-MPH) ligand by surface ligand exchange. The surface-functionalized AuNRs (4-MPH-AuNRs) exhibited a typical UV–vis spectrum of AuNRs with a slightly shifted longitudinal peak. Furthermore, 4-MPH-AuNRs demonstrated a similar Fourier-Transformed Infrared spectrum to 4-MPH and a fading of the thiol band, which suggests a successful functionalization through thiol-gold binding. The antibacterial and antibiofilm activities of 4-MPH-AuNRs were evaluated against a clinical isolate of Methicillin-Resistant Staphylococcus aureus (MRSA). The results indicate that 4-MPH-AuNRs exhibit a bactericidal activity with a minimum inhibitory concentration (MIC) of ~ 6.25 μ g/mL against a planktonic suspension of MRSA. Furthermore, 4-MPH-AuNRs resulted in a 1.8–2.9 log-cycle reduction of MRSA biofilm viable count over a concentration range of 100–6.0 μ g/mL. The bacterial uptake of the surface-modified nanorods was investigated by inductively coupled plasma-optical emission spectroscopy (ICP-OES) and scanning electron microscopy (SEM) imaging; the results reveal that the nanorods were internalized into the bacterial cells after 6 h (h) of exposure. SEM imaging revealed a significant accumulation of the nanorods at the bacterial cell wall and a possible cellular internalization. Thus, 4-MPH-AuNRs can be considered a potential antibacterial agent, particularly against MRSA strain biofilms.
راعي المشروعOpen Access funding provided by the Qatar National Library. Funding was provided by Al-Zaytoonah University of Jordan (2020-2019/12/28) and Qatar University (BRC-2021-ID-02, QUST-2-CHS-2021-2019).
اللغةen
الناشرSpringer
الموضوع4-mercaptophenol
Antibiofilm
Bactericidal activity
Gold nanorods
MIC
MRSA
العنوانAntibacterial and Antibiofilm Activity of Mercaptophenol Functionalized-Gold Nanorods Against a Clinical Isolate of Methicillin-Resistant Staphylococcus aureus
النوعArticle
ESSN1574-1451
dc.accessType Open Access


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