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AuthorSheikh, Emana
AuthorTran, Tony
AuthorVranic, Semir
AuthorLevy, Arkene
AuthorBonfil, R Daniel
Available date2022-05-10T08:19:40Z
Publication Date2022-04-27
Publication NameBosnian Journal of Basic Medical Sciences
Identifierhttp://dx.doi.org/10.17305/bjbms.2021.7399
CitationSheikh E, Tran T, Vranic S, Levy A, Bonfil RD. Role and Significance of c-KIT Receptor Tyrosine Kinase in Cancer: A Review. Bosn J of Basic Med Sci [Internet]. 2022Apr.27 [cited 2022May10];. Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/7399
ISSN1512-8601
URIhttp://hdl.handle.net/10576/30801
Abstractc-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK) that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell proliferation, survival, and migration and is implicated in several physiological processes, including pigmentation, hematopoiesis and gut movement. Accumulating evidence suggests that dysregulated c-KIT function, caused by either overexpression or mutations in c-kit, promotes tumor development and progression in various human cancers. In this review, we discuss the most important structural and biological features of c-KIT, as well as insights into the activation of intracellular signaling pathways following SCF binding to this RTK. We then illustrate how different c-kit alterations are associated with specific human cancers and describe recent studies that highlight the contribution of c-KIT to cancer stemness, epithelial-mesenchymal transition and progression to metastatic disease in different experimental models. The impact of tyrosine kinase inhibitors in treating c-KIT-positive tumors and limitations due to their propensity to develop drug resistance are summarized. Finally, we appraise the potential of novel therapeutic approaches targeting c-KIT more selectively while minimizing toxicity to normal tissue.
Languageen
PublisherAssociation of Basic Medical Sciences of Federation of Bosnia and Herzegovina
Subjectmelanoma
genetics
TitleRole and Significance of c-KIT Receptor Tyrosine Kinase in Cancer: A Review.
TypeArticle Review
ESSN1840-4812
dc.accessType Open Access


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