Browsing Medicine Research by Author "Georgakopoulos-Soares, Ilias"
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Distinct genomic features across cytolytic subgroups in skin melanoma.
Roufas, Constantinos; Georgakopoulos-Soares, Ilias; Zaravinos, Apostolos ( Springer , 2021 , Article)Skin melanoma is a highly immunogenic cancer. The intratumoral immune cytolytic activity (CYT) reflects the ability of cytotoxic T and NK cells to eliminate cancer cells, and is associated with improved patient survival. ... -
EMT Factors and Metabolic Pathways in Cancer.
Georgakopoulos-Soares, Ilias; Chartoumpekis, Dionysios V.; Kyriazopoulou, Venetsana; Apostolos, Zaravinos ( Frontiers Media , 2020 , Article)The epithelial-mesenchymal transition (EMT) represents a biological program during which epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is normally observed during organismal development, ... -
Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis
Roufas, Constantinos; Georgakopoulos-Soares, Ilias; Zaravinos, Apostolos ( Oxford University Press , 2021 , Article)Although immune checkpoint inhibition (ICI) has shown promising results in metastatic dMMR/MSI-H colorectal cancer (CRC), the majority of pMMR/MSS patients do not respond to such therapies. To systematically evaluate the ...