Browsing Medicine Research by Author "n 84052742"

Now showing items 1-6 of 6

    • Blood pressure and bladder cancer risk in men by use of survival analysis and in interaction with NAT2 genotype, and by Mendelian randomization analysis 

      Teleka, Stanley; Hindy, George; Drake, Isabel; Poveda, Alaitz; Melander, Olle; ... more authors ( Public Library of Science , 2020 , Article)
      The association between blood pressure (BP) and bladder cancer (BC) risk remains unclear with confounding by smoking being of particular concern. We investigated the association between BP and BC risk among men using ...

    • Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants 

      Aragam, Krishna G.; Jiang, Tao; Goel, Anuj; Kanoni, Stavroula; Wolford, Brooke N.; ... more authors ( Nature Research , 2022 , Article)
      The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) ...

    • Genome-wide polygenic score, clinical risk factors, and long-term trajectories of coronary artery disease 

      Hindy, George; Aragam, Krishna G.; Ng, Kenney; Chaffin, Mark; Lotta, Luca A.; ... more authors ( American Heart Association , 2020 , Article)
      OBJECTIVE: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, ...

    • Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis 

      Hindy, George; Tyrrell, Daniel J.; Vasbinder, Alexi; Wei, Changli; Presswalla, Feriel; ... more authors ( American Society for Clinical Investigation , 2022 , Article)
      People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which ...

    • Methodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort 

      Drake, Isabel; Hindy, George; Almgren, Peter; Engström, Gunnar; Nilsson, Jan; ... more authors ( Nature Research , 2021 , Article)
      Novel methods to characterize the plasma proteome has made it possible to examine a wide range of proteins in large longitudinal cohort studies, but the complexity of the human proteome makes it difficult to identify robust ...

    • Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes 

      George, Hindy; Dornbos, Peter; Chaffin, Mark D.; Liu, Dajiang J.; Wang, Minxian; ... more authors ( Elsevier , 2022 , Article)
      Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele ...