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Comprehensive analysis of cancers of unknown primary for the biomarkers of response to immune checkpoint blockade therapy
( Elsevier Ltd , 2018 , Article)Background: Cancer of unknown primary (CUP) accounts for approximately 3% of all malignancies. Avoiding immune destruction is a major cancer characteristic and therapies aimed at immune checkpoint blockade are in use for ... -
Cytokine responses in campylobacteriosis: Linking pathogenesis to immunity
( Elsevier Ltd , 2018 , Article Review)Campylobacter jejuni is an important enteric pathogen that causes diarrheas of different degrees of severity and several extra-intestinal manifestations, including Guillain-Barre syndrome. The variability of disease outcomes ... -
Flight Versus Ground Out-of-hospital Rapid Sequence Intubation Success: a Systematic Review and Meta-analysis
( Taylor and Francis Ltd , 2018 , Article)Introduction: Endotracheal intubation (ETI) is a critical procedure performed by both air medical and ground based emergency medical services (EMS). Previous work has suggested that ETI success rates are greater for air ... -
In Response: Heterogeneous and dynamic prevalence of asymptomatic influenza virus infections
( Centers for Disease Control and Prevention (CDC) , 2018 , Article)In Response: We thank Leung and Cowling (1) for taking time to comment on our article (2). One problem with the random effects model is the rapid decline in performance of the model as the heterogeneity within studies ... -
COL4A5 and LAMA5 variants co-inherited in familial hematuria: Digenic inheritance or genetic modifier effect?
( BioMed Central Ltd. , 2018 , Article)Background: About 40-50% of patients with familial microscopic hematuria (FMH) caused by thin basement membrane nephropathy (TBMN) inherit heterozygous mutations in collagen IV genes (COL4A3, COL4A4). On long follow-up, ... -
Novel whole-cell inactivated Neisseria gonorrhoeae microparticles as vaccine formulation in microneedle-based transdermal immunization
( MDPI AG , 2018 , Article)Neisseria gonorrhoeae is a strict human pathogen responsible for more than 100 million new sexually transmitted infections worldwide each year. Due to the global emergence of antibiotic resistance, the Center for Disease ... -
Quality improvement can decrease blood delivery turnaround time: Evidence from a single tertiary-care academic medical center
( American University of Beirut , 2018 , Article)Context: Blood transfusion services are critical to any hospitals? functioning, and timely blood/ component therapy resuscitation is lifesaving. Yet, few blood delivery turnaround time (TAT) studies have been undertaken. ... -
The 4-hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions
( Spandidos Publications , 2018 , Article)Lipid peroxidation is associated with several metabolic diseases. Lipid peroxidation causes cellular damage through reactive aldehyde species such as 4-hydroxyonenal (4-HNE). The exact mechanism(s) by which 4-HNE causes ... -
Voltage dependence of the Ca2+ transient in endocardial and epicardial myocytes from the left ventricle of Goto Kakizaki type 2 diabetic rats
( Springer New York LLC , 2018 , Article)Diabetes mellitus is a major global health disorder and, currently, over 450 million people have diabetes with 90% suffering from type 2 diabetes. Left untreated, diabetes may lead to cardiovascular diseases which are a ... -
Signaling pathways activated by PACAP in MCF-7 breast cancer cells
( Elsevier Inc. , 2018 , Article)PACAP has opposing roles ranging from activation to inhibition of tumor growth and PACAP agonists/antagonists could be used in tumor therapy. In this study, the effect of PACAP stimulation on signaling pathways was ... -
Identification of FAM173B as a protein methyltransferase promoting chronic pain
( Public Library of Science , 2018 , Article)Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic ... -
A cephalometric morphometric study of age- and gender-dependent shape patterns of the sella turcica
(2018 , Article)The sella turcica is an important anatomic and radiologic entity. The shape of the sella turcica varies among normal individuals and can be influenced by local factors. The normal shape of sella turcica has been categorized ... -
Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions [version 1; referees: 2 approved]
( F1000 Research Ltd , 2018 , Article)Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal ... -
Taxonomy of communications in the operating room
( Springer Verlag , 2018 , Conference Paper)US hospitals are facing critical problems of nurse shortage. One report predicts that there will be a shortage of 260,000 registered nurses by 2025 in the USA, and it was found out that patient mortality risk is 6% higher ... -
Expression of sperm PLC? and clinical outcomes of ICSI-AOA in men affected by globozoospermia due to DPY19L2 deletion
( Elsevier Ltd , 2018 , Article)Globozoospermia is characterized by the presence of 100% acrosomeless round-headed spermatozoa in an ejaculate. Failed fertilization after intracytoplasmic sperm injection (ICSI) is commonly reported for globozoospermic ... -
Group OSCE (GOSCE) as a formative clinical assessment tool for pre-clerkship medical students at the University of Sharjah
( Elsevier B.V. , 2018 , Article)Objectives: Continuous formative assessment with appropriate feedback is the pillar of effective clinical teaching and learning. Group Objective Structured Clinical Examination (GOSCE) has been reported as a resource-effective ... -
Elaeagnus angustifolia Plant Extract Inhibits Angiogenesis and Downgrades Cell Invasion of Human Oral Cancer Cells via Erk1/Erk2 Inactivation.
( Taylor & Francis (Routledge) , 2018 , Article)Oral cancer is a common malignancy in both men and women worldwide; this cancer is characterized by a marked propensity for invasion and spreading to local lymph nodes. On the other hand, Elaeagnus angustifolia (EA) is a ... -
Perspectives and attitudes of jordanian medical and paramedical students toward surrogate pregnancy
( Taylor & Francis Group , 2018 , Article)Purpose: This study aims at investigating the perspectives of Jordanian medical and paramedical students on surrogate pregnancy. Methods: A questionnaire-based cross-sectional study design was used. The sample consisted ... -
HER-2/Epstein-Barr virus crosstalk in human gastric carcinogenesis: A novel concept of oncogene/oncovirus interaction.
( Taylor & Francis , 2018 , Article)Gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths worldwide. Additionally, it is well-known that metastatic cancer disease is a major cause of morbidity and mortality in cancer ... -
Comprehensive molecular profiling of advanced/metastatic olfactory neuroblastomas.
( Public Library of Science , 2018 , Article)Olfactory neuroblastoma (ONB) is a rare, locally aggressive, malignant neoplasm originating in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and there are no specific treatment ...