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2-Nucleobase-substituted 4,6-Diaminotriazine Analogs: Synthesis and Anti-cancer Activity in 5-Fluorouracil-Sensitive and Resistant Colorectal Cancer Cells.
( Bentham Science Publishers , 2022 , Article)Cancer continues to be the second leading cause of death worldwide with colorectal cancer (CRC) being the third most common type. Despite significant advances in cancer therapies, current treatment of CRC remains suboptimal. ... -
Cannabinoids and Myocardial Ischemia: Novel insights, Updated Mechanisms, and Implications for Myocardial Infarction
( Bentham Science Publishers , 2022 , Article)Cannabis is the most widely trafficked and abused illicit drug due to its calming psychoactive properties. It has been increasingly recognized as having potential health benefits and relatively less adverse health effects ... -
Drug Repurposing in Vasculo-metabolic Diseases
( Bentham Science Publishers , 2023 , Other)Drug repurposing or repositioning is an approach that seeks to maximize the use of existing drugs by identifying new indications other than the ones for which the drug was initially conceived [1-5]. This approach has been ... -
The Effects of Statin Therapy on Circulating Levels of Trimethylamine N-oxide: A Systematic Review and Meta-analysis
( Bentham Science Publishers , 2023 , Article)Background Gut microbiota is associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD) through the metabolites, which can induce atherogenesis. One of these metabolites is trimethylamine N-oxide ... -
Estrogen receptor and the gender bias in Raynaud's phenomenon.
( Bentham Science Publishers , 2023 , Other)Cold-induced vasoconstriction is a normal physiological reaction aiming at redirecting blood into internal more vital body organs [1]. It is mediated by sympathetic release of norepinephrine as well as by local effectors ... -
Identification of SER-PRO-CYS Peptide in Blood Serum of Multiple Sclerosis Patients
( Bentham Science Publishers , 2016 , Article)Monitoring of multiple sclerosis (MS) requires additional molecular markers. Recently, we used original TCA-precipitation/extraction approach in combination with MALDI TOF/TOF mass-spectrometry and identified earlier unknown ... -
Nanomedicine for Cancer.
( Bentham Science Publishers , 2022 , Other)Over the past decades, oncology has occupied the lion’s share of all nanomedical applications [1-3]. In 2020, up to 65% of the clinical trials involving nanomaterials were attending to cancer therapeutics and diagnostics ... -
Novel polymethoxylated chalcones as potential compounds against kras-mutant colorectal cancers
( Bentham Science Publishers , 2020 , Article)Background/Objective: KRAS-mutant colorectal cancers (CRC) are tumors that are associated with poor prognosis. However, no effective treatments are available to target them. Therefore, we designed and synthesized novel ... -
Selective Activation of G protein-coupled Estrogen Receptor 1 Attenuates Atherosclerosis.
( Bentham Science Publishers , 2023 , Article Review)Atherosclerosis remains a leading contributor to cardiovascular disease-associated morbidity and mortality. Interestingly, the death rate is higher in men than women from atherosclerosis, and the risk increases for ... -
Vascular inflammation: Players and modulators
( Bentham Science Publishers , 2021 , Other)-