Browsing Medicine Research by Publisher "American Society for Clinical Investigation"

Now showing items 1-3 of 3

    • Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity 

      Castro J.; Harrington A.M.; Lieu T.M.; Garcia-Caraballo S.; Maddern J.; ... more authors ( American Society for Clinical Investigation , 2019 , Article)
      Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal or avoidance of tissue damage. While pain arises from both the skin and viscera, we investigated whether pruritogenic irritant ...

    • Failed immune responses across multiple pathologies share pan-tumor and circulating lymphocytic targets 

      Monette, Anne; Morou, Antigoni; Al-Banna, Nadia A.; Rousseau, Louise; Lattouf, Jean-Baptiste; ... more authors ( American Society for Clinical Investigation , 2019 , Article)
      Tumor-infiltrating lymphocytes (TILs) are widely associated with positive outcomes, yet carry key indicators of a systemic failed immune response against unresolved cancer. Cancer immunotherapies can reverse their tolerance ...

    • Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis 

      Hindy, George; Tyrrell, Daniel J.; Vasbinder, Alexi; Wei, Changli; Presswalla, Feriel; ... more authors ( American Society for Clinical Investigation , 2022 , Article)
      People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which ...