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High expression of immune checkpoints is associated with the TIL load, mutation rate and patient survival in colorectal cancer.
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Spandidos Publications
, 2020 , Article)
Adoptive cell therapy with the use of tumor-infiltrating lymphocytes (TILs) is a very promising immunotherapeutic approach for the treatment of patients with colorectal cancer (CRC). However, within the tumor microenvironment, ...
Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 Infection
(
Frontiers Media
, 2020 , Article)
The global pandemic of COVID-19 disease caused by infection with the SARS-CoV-2 coronavirus, has produced an urgent requirement and search for improved treatments while effective vaccines are developed. A strategy for ...
Construct validity of an instrument for assessment of reflective writing-based portfolios of medical students
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Dove Medical Press
, 2020 , Article)
Purpose: Assessment of reflective writing for medical students is challenging, and there is lack of an available instrument with good psychometric properties. The authors developed a new instrument for assessment of ...
Emotional and Clinical Challenges While Dealing With a Blind-Deaf-Mute Patient.
(
Springer
, 2020 , Article)
A 43-year-old male, known to be deaf, mute, and blind, presented to the ED accompanied by his daughter. She said that he had multiple episodes of diarrhea and vomiting for two days. At first, it gave the impression of ...
Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer
(
BMJ Publishing Group
, 2020 , Article)
Introduction Patients with diabetes have increased risk of periodontal disease, with increased risk of weakening of periodontal ligament and tooth loss. Periodontal ligament is produced and maintained by periodontal ligament ...
Polypharmacy and drug interactions amongst cirrhotic patients discharged from a tertiary center: Results from a national quality improvement audit
(
Elsevier
, 2020 , Article)
Background and Study AimsAuditing of polypharmacy is particularly essential in patients with cirrhosis because of the crucial role of liver in drug metabolism. The aim of this study was to audit the drug prescribed in this ...
Research on elastic recoil and restoration of vessel pulsatility of Zn-Cu biodegradable coronary stents
(
De Gruyter
, 2020 , Article)
Coronary stents made of zinc (Zn)-0.8 copper (Cu) (in wt%) alloy were developed as biodegradable metal stents (Zn-Cu stents) in this study. The mechanical properties of the Zn-Cu stents and the possible gain effects were ...
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity
(
Springer Nature
, 2020 , Article)
Synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are characterized by pathological accumulation of α-synuclein (α-syn). Amongst the various approaches ...
An Investigation into the Association Between Inflammatory Bowel Disease and Cardiac Arrhythmias: An Examination of the United States National Inpatient Sample Database
(
SAGE Publications
, 2020 , Article)
Background: Inflammatory bowel diseases (IBD) associated-chronic inflammation and autonomic dysregulation may predispose to arrhythmias. However, its exact prevalence is unknown. Thus, we aimed to ascertain the prevalence ...
An unusual case of modified Lemierre’s syndrome caused by staphylococcus aureus cellulitis
(
International Scientific Literature Inc.
, 2020 , Article)
Patient: Male, 31-year-old
Final Diagnosis: Lemierre’s Disease
Symptoms: Conjunctival injection • eye pain and redness • fever • nasal swelling • periorbital oedema • ptosis • vesicular lesions nose
Medication: — Clinical ...