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Metformin is comparable to insulin for pharmacotherapy in gestational diabetes mellitus: A network meta-analysis evaluating 6046 women.
(
Elsevier
, 2021 , Article)
The comparative efficacy of gestational diabetes (GDM) treatments lack conclusive evidence for choice of first-line treatment. The aim of this study was to compare the efficacy of metformin and glibenclamide to insulin ...
Neuronal Cell Types in the Anterior Ventral Thalamic Nucleus of the Camel.
(
Wiley
, 2021 , Article)
The anterior ventral nucleus neurons in of the camel brain were morphologically studied by Golgi impregnation method. Two neuronal types of were found in the camel anterior ventral thalamic nucleus, namely, Golgi-type I ...
Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity
(
Elsevier
, 2021 , Article)
Obesity is a global burden and a chronic ailment with damaging overall health effects. Ghrelin, an octanoylated 28 amino acid peptide hormone, is secreted from the oxyntic mucosa of the stomach. Ghrelin acts on regions of ...
Methodological issues of systematic reviews and meta-analyses in the field of sleep medicine: A meta-epidemiological study
(
Elsevier
, 2021 , Article)
An increasing number of systematic reviews and meta-analyses (SRMAs) have been published in the field of sleep medicine. We evaluated the methodological issues of these SRMAs. A protocol was developed in advance. Three ...
Unexpected adrenal pheochromocytoma associated with a generalized tonic-clonic seizure in a prepubertal boy: A case report.
(
Lippincott, Williams & Wilkins
, 2021 , Article)
Pheochromocytoma (PHEO) is a rare neuroendocrine tumor arising from chromaffin cells of the adrenal medulla. Most pediatric PHEOs are functional tumors, and clinical manifestations are related to catecholamine hypersecretion ...
Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered
(
Elsevier
, 2021 , Article)
Background and ObjectiveMeta-analysis is a statistical method with the ability to increase the power for statistical inference, while it may still face the problem of being underpowered. In this study, we investigated the ...
Regulation of NKG2D by RKIP: Implications on NK-mediated cytotoxicity and cytokine production
(
Elsevier
, 2021 , Book chapter)
RKIP (Raf kinase inhibitory protein) is a metastatic suppressor and a chemo-immuno-sensitizer. The deficiency or loss of RKIP has been linked with different cancer types, resulting in the activation of the MAPK pathway, ...
Information, Thermodynamics and Life: A Narrative Review
(
MDPI
, 2021 , Article Review)
Information is probably one of the most difficult physical quantities to comprehend. This applies not only to the very definition of information, but also to the physical entity of information, meaning how can it be ...
Oncoproteins of High-Risk HPV and EBV Cooperate to Enhance Cell Motility and Invasion of Human Breast Cancer Cells Erk1/Erk2 and β-Catenin Signaling Pathways.
(
Frontiers Media
, 2021 , Article)
Breast cancer is a leading cause of death in women around the world. Most breast cancer-related deaths are a result of complications from the metastatic spread. Several recent studies reported that high-risk human ...
A comparison of the prevalence of sexually transmitted infections among circumcised and uncircumcised adult males in Rustenburg, South Africa: a cross-sectional study.
(
BMC
, 2021 , Article)
South Africa has a persistent burden of sexually transmitted infections (STIs). Male circumcision has been shown to be effective in preventing HIV and STIs, but data are scarce on the protective effect of circumcision in ...