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Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria
(
Portland Press Ltd
, 2024 , Article)
Homocystinuria is a rare disease caused by mutations in the CBS gene that results in a deficiency of cystathionine β-synthase (CBS). CBS is an essential pyridoxal 50-phosphate (PLP)-dependent enzyme in the transsulfuration ...
Expression of sperm PLC? and clinical outcomes of ICSI-AOA in men affected by globozoospermia due to DPY19L2 deletion
(
Elsevier Ltd
, 2018 , Article)
Globozoospermia is characterized by the presence of 100% acrosomeless round-headed spermatozoa in an ejaculate. Failed fertilization after intracytoplasmic sperm injection (ICSI) is commonly reported for globozoospermic ...
The relationship between oxidative stress and apoptosis of histopathological changes in the ovary made by mad honey containing grayanotoxin
(
Elsevier
, 2024 , Article)
The purpose of this study is to determine the effects of grayanotoxin in mad honey on ovarian tissue folliculogenesis in terms of cell death and nitric oxide expression. Three groups of 18 female Sprague-Dawley rats were ...
Continuity of sleep problems from adolescence to young adulthood: results from a longitudinal study
(
Elsevier Inc
, 2017 , Article)
Background
Considering the lack of evidence on incidence and continuity of sleep problems from adolescence to young adulthood, this study explores sleep problems’ incidence and their continuation rates from 14 to 21 ...
Thujone inhibits the function of 7-nicotinic acetylcholine receptors and impairs nicotine-induced memory enhancement in one-trial passive avoidance paradigm
(
Elsevier Ireland Ltd
, 2017 , Article)
Effects of thujone, a major ingredient of absinthe, wormwood oil and some herbal medicines, were tested on the function of 7 subunit of the human nicotinic acetylcholine (7 nACh) receptor expressed in Xenopus oocytes using ...
Effectiveness of Different Topical Treatments in the Healing of Pressure Injuries: A Network Meta-analysis.
(
Elsevier
, 2018 , Article)
Pressure injuries (PIs) are one of the most common types of complex wounds and impose a huge economic burden on the healthcare system and the patients. A plethora of topical treatments is widely available for PI treatment, ...
P-value driven methods were underpowered to detect publication bias: analysis of Cochrane review meta-analyses
(
Elsevier
, 2019 , Article)
To investigate the effect of number of studies in a meta-analysis on the detection of publication bias using p-value driven methods. The proportion of meta-analyses detected by Egger's, Harbord's, Peters', and Begg's tests ...
PD-L1 status in breast cancer: Current view and perspectives.
(
Elsevier
, 2019 , Article)
Breast cancer was traditionally not considered a particularly immunogenic tumor. However, recent developments have shown that some aggressive triple-negative breast cancers are immunogenic, exhibit a resistance to chemotherapy ...
Implementation and evaluation of a patient safety course in a problem-based learning program
(2017 , Article)
Background: Since the development of the WHO patient safety curriculum guide, there has been insufficient reporting regarding the implementation and evaluation of patient safety courses in undergraduate problem-based ...
Perspectives of healthcare workers on integrated management of childhood illness in Pakistan: A phenomenological approach
(
SAGE
, 2024 , Article)
In 2019, an estimated 5.2 million deaths were reported among children less than 5 years of age. At primary healthcare level, healthcare workers (HCWs) mostly rely on history and clinical findings and less on inadequate ...