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In honour of Professor Patrick Couvreur, recipient of the Journal Of Drug Targeting?s Lifetime Achievement Award For 2019
(
Taylor and Francis Ltd
, 2019 , Article)
[No abstract available]
Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs
(
American Chemical Society
, 2019 , Article)
G-protein-coupled receptors (GPCRs) can bias signaling through distinct biochemical pathways that originate from G-protein/receptor and β-arrestin/receptor complexes. Receptor conformations supporting β-arrestin engagement ...
Drug-free holidays: Compliance, tolerability, and acceptability of a 3-day atovaquone/proguanil schedule for pretravel malaria chemoprophylaxis in australian travelers
(
Oxford University Press
, 2019 , Article)
Background
Poor compliance with chemoprophylaxis is a major contributing factor to the risk of malaria in travelers. Pre-travel chemoprophylaxis may improve compliance by enabling “drug-free holidays.” The standard treatment ...
Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity
(
Elsevier
, 2019 , Article)
The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally ...
The Arrhythmogenic E105A CAM Mutation Dysregulates Normal Cardiac Function in Zebrafish by Altering CAM-Ca2+ and CAM-RyR2 Interactions
(
Elsevier
, 2019 , Article)
Calmodulin (CaM) is a multifunctional calcium (Ca2+)-binding messenger that directly interacts with the cardiac ryanodine receptor 2 (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ...
Autism spectrum disorder: A concept in evolution
(
slack journals
, 2019 , Article)
Autism is a fascinating topic that has attracted the interest of researchers and the lay public alike. The history of autism is filled with accomplishments of people who were astute observers of childhood psychopathology. ...
Maspin differential expression patterns as a potential marker for targeted screening of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma.
(
Public Library of Science
, 2019 , Article)
Barrett's esophagus (BE) is a predisposing factor of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma (ECA/GEJ Aca). BE patients are stratified and subsequently monitored according to the risk of malignant ...
Encysted hydrocele of the canal of Nuck in an 11-month-old child with a past history of duodenal atresia and Arnold-Chiari malformation: A case report.
(
Wolters Kluwer Health
, 2019 , Article)
Hydrocele of the canal of Nuck is a rare developmental disorder and represents of a homolog of hydrocele of spermatic cord in males. Hydrocele of the canal of Nuck is a very rare cause of inguinal swelling in female infants ...
Letter to Editor: Apocrine carcinoma is the fact. Comment on the recent paper entitled "Invasive apocrine carcinoma of the breast: Myth or fact?" by Gurrado et al (Breast J. 2019 Sep 8. doi: 10.1111/tbj.13569. [Epub ahead of print].
(
Wiley
, 2019 , Article)
The most recent WHO classification of breast cancer also recognizes the concept of “pure apocrine carcinoma” (called carcinoma with apocrine differentiation) with cancers having >90% of apocrine morphology (an essential ...
Investigating the blood-host plasticity and dispersal of Anopheles coluzzii using a novel field-based methodology
(
BioMed Central Ltd.
, 2019 , Article)
Background: The biting behaviour and dispersal of insect vectors in the field underlies the transmission of many diseases. Here, a novel collection methodology coupled with the molecular analysis of blood-meal sources and ...