Medicine Research: Recent submissions
Now showing items 1401-1420 of 1739
-
Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar
( Elsevier , 2020 , Article)ObjectiveTo estimate the age- and nationality-specific West Nile virus (WNV) seroprevalence in select Middle East and North Africa (MENA) populations residing in Qatar. MethodsSera were collected from male blood donors ... -
Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLC?
( Portland Press Ltd , 2017 , Article)Sperm-specific phospholipase C zeta (PLC?) is widely considered to be the physiological stimulus that evokes intracellular calcium (Ca2+) oscillations that are essential for the initiation of egg activation during mammalian ... -
Duration of symptoms is the only predictor of testicular salvage following testicular torsion in children: A case-control study
( Elsevier , 2020 , Article)ObjectiveTesticular torsion (TT) is an emergency requiring a prompt diagnosis and surgery to avoid irreversible changes and a complete loss of testis. The present study aimed to identify potential factors that may be predict ... -
Molecular Profiling Reveals Limited Targetable Biomarkers in Neuroendocrine Carcinoma of the Cervix.
( Lippincott, Williams & Wilkins , 2020 , Article)Neuroendocrine carcinoma of the cervix (NEC) is a rare and highly aggressive cervical malignancy. Given that no targeted therapy has been approved specifically to NEC, we investigated the presence of novel, potentially ... -
Islam and Mental Disorders of the Older Adults: Religious Text, Belief System and Caregiving Practices.
( Springer , 2020 , Article)This paper illustrates the impact of Islamic religious texts on dementia care in the Middle East. It examines how old age and older adults mental disorders are framed in the Quran and Hadith, and how these texts are ... -
Controversy and Debate: Questionable utility of the relative risk in clinical research: Paper 1: A call for change to practice
( Elsevier , 2020 , Article)Background and Objectives In clinical trials, the relative risk or risk ratio (RR) is a mainstay of reporting of the effect magnitude for an intervention. The RR is the ratio of the probability of an outcome in an ... -
68 Ga-PSMA PET/CT tumour intensity pre-operatively predicts adverse pathological outcomes and progression-free survival in localised prostate cancer
( Springer , 2020 , Article)© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Prostate-specific membrane antigen (PSMA) positron emission tomography (PSMA-PET) improves prostate cancer staging. Intraprostatic PSMA intensity may ... -
Global incidence of caesarean deliveries on maternal request: a systematic review and meta-regression.
( Wiley , 2020 , Article)Caesarean delivery on maternal request (CDMR) is considered a significant contributor to the unprecedented increase in caesarean deliveries (CDs) for nonclinical reasons. Current literature lacks a reliable assessment of ... -
Physical activity in pregnancy prevents gestational diabetes: A meta-analysis
( Elsevier , 2020 , Article)AimsThe effectiveness of physical activity (PA) programs for prevention of gestational diabetes (GDM) lacks conclusive evidence. The aim of this study was to generate clear evidence regarding the effectiveness of physical ... -
A Biomarker Based Severity Progression Indicator for COVID-19: The Kuwait Prognosis Indicator Score.
( Taylor and Francis , 2020 , Article)COVID-19 is a worldwide pandemic that is mild in most patients but can result in a pneumonia like illness with progression to acute respiratory distress syndrome and death. Predicting the disease severity at time of diagnosis ... -
Performance evaluation of five ELISA kits for detecting anti-SARS-COV-2 IgG antibodies
( Elsevier , 2020 , Article)ObjectivesTo evaluate and compare the performances of five commercial ELISA assays (EDI, AnshLabs, Dia.Pro, NovaTec, and Lionex) for detecting anti-SARS-CoV-2 IgG. Methods70 negative control samples (collected before the ... -
EMT Factors and Metabolic Pathways in Cancer.
( Frontiers Media , 2020 , Article)The epithelial-mesenchymal transition (EMT) represents a biological program during which epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is normally observed during organismal development, ... -
Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer.
( Nature Research , 2020 , Article)The deregulated genes in colorectal cancer (CRC) vary significantly across different studies. Thus, a systems biology approach is needed to identify the co-deregulated genes (co-DEGs), explore their molecular networks, and ... -
The efficacy of colchicine in the management of coronavirus disease 2019: A protocol for systematic review and meta-analysis
( Lippincott, Williams & Wilkins , 2020 , Article)BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) infection is a recently emerged viral infection causing predominantly mild upper respiratory symptoms. However, in some instances, it might result in ... -
Silencing of Growth Differentiation Factor-15 Promotes Breast Cancer Cell Invasion by Down-regulating Focal Adhesion Genes.
( International Institute of Anticancer Research , 2020 , Article)As metastasis accounts for most breast cancer (BC)-related deaths, identifying key players becomes research priority. Growth differentiation factor-15 (GDF15), a member of the transforming growth factor-β superfamily, is ... -
High expression of immune checkpoints is associated with the TIL load, mutation rate and patient survival in colorectal cancer.
( Spandidos Publications , 2020 , Article)Adoptive cell therapy with the use of tumor-infiltrating lymphocytes (TILs) is a very promising immunotherapeutic approach for the treatment of patients with colorectal cancer (CRC). However, within the tumor microenvironment, ... -
Macrophage responses associated with COVID-19: A pharmacological perspective
( Elsevier , 2020 , Article)COVID-19 has caused worldwide death and economic destruction. The pandemic is the result of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has demonstrated high rates of infectivity leading to great ... -
ILK silencing inhibits migration and invasion of more invasive glioblastoma cells by downregulating ROCK1 and Fascin-1.
( Springer , 2020 , Article)Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor and it is associated with poor survival. Integrin-linked kinase (ILK) is a serine/threonine protein pseudo-kinase that binds to the cytoplasmic domains ... -
The Non-Coding RNA and Its Role in Tumor Therapy-Induced Resistance.
( MDPI , 2020 , Article)The growth arrest-specific transcript 5 () is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, ... -
Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers.
( Public Library of Science , 2020 , Article)Octamer binding transcription factor-4 (Oct4), is highly expressed in stem cells and has indispensable roles in pluripotency and cellular reprogramming. In contrast to other factors used for cellular reprogramming, a role ...
