Medicine Research: Recent submissions
Now showing items 1201-1220 of 1794
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Role and Significance of c-KIT Receptor Tyrosine Kinase in Cancer: A Review.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2022 , Article Review)c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK) that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell proliferation, survival, and migration and is ... -
Antibacterial and Antibiofilm Activity of Mercaptophenol Functionalized-Gold Nanorods Against a Clinical Isolate of Methicillin-Resistant Staphylococcus aureus
( Springer , 2022 , Article)Gold nanorods (AuNRs) were synthesized by the seed-mediated wet chemical method using a binary surfactant system. AuNRs were stabilized with polyethylene glycol, then functionalized with 4-mercaptophenol (4-MPH) ligand by ... -
Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2022 , Article Review)Melanoma is a highly aggressive cancer originating from melanocytes. Its etiopathogenesis is strongly related to genetic, epigenetic, and environmental factors. Melanomas encountered in clinical practice are predominantly ... -
Advancing male age differentially alters levels and localization patterns of PLCzeta in sperm and testes from different mouse strains
( Medknow Publications , 2021 , Article)Sperm-specific phospholipase C zeta (PLC) initiates intracellular calcium (Ca2+) transients which drive a series of concurrent events collectively termed oocyte activation. Numerous investigations have linked abrogation ... -
Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients
( Elsevier , 2022 , Article Review)Over the past two decades, diabetes mellitus (DM) has been receiving increasing attention among autoimmune diseases. The prevalence of type 1 and type 2 diabetes has increased rapidly and has become one of the leading ... -
Thrombin generation measured on ST Genesia, a new platform in the coagulation routine lab: Assessment of analytical and between-subject variation
( Wiley Open Access , 2022 , Article)Background: The thrombin generation (TG) assay, which measures global coagulation, has mainly been used as a research tool to investigate thrombotic and bleeding disorders. Recently, Diagnostica Stago launched the ST ... -
Mechanisms underlying the effects of caloric restriction on hypertension
( Elsevier , 2022 , Article)Hypertension is a major risk factor for cardiovascular disease (CVD) as well as a major contributor to all-cause mortality and disability worldwide. The pathophysiology of hypertension is highly attributed to a dysfunctional ... -
Increased de novo DNA methylation enzymes in sperm of individuals with varicocele
( pmc , 2021 , Article)Objective: Chronic genital heat-stress associated with varicocele leads to DNA hypo-methylation of spermatozoa. The objective of this study was comparing level of DNA methyl-transferases (DNMTs) in sperm of men suffering ... -
Pyridoxine non-responsive p.R336C mutation alters the molecular properties of cystathionine beta-synthase leading to severe homocystinuria phenotype
( Elsevier , 2022 , Article)The prevalence of homocystinuria in Qatar is 1:1800, mainly due to a founder missense mutation p.R336C. • The cystathionine beta-synthase (CBS) R336C mutant was bacterially expressed, purified and its molecular properties ... -
Driver Drowsiness Detection Study using Heart Rate Variability analysis in Virtual Reality Environment
( Hamad bin Khalifa University Press (HBKU Press) , 2018 , Conference)Introduction Mobility and road safety is one of the grand challenges that Qatar is facing during the last decade. There are many ways to enhance the road safety. One way is to characterize the factors contributing to the ... -
Frequency of Parathyroid Hormone Assessment in the Evaluation of Hypercalcemia. A Comparison Between Patients With and Without a History of Malignancy in a 20-year Dataset of 20,954 Patients
( SAGE Publications Ltd , 2021 , Article)Background: The purpose of this study was to evaluate whether a prior diagnosis of malignancy affected the assessment of parathyroid hormone (PTH) in hypercalcemic patients and whether the rate of this assessment changed ... -
The Odds Ratio is "portable" across baseline risk but not the Relative Risk: Time to do away with the log link in binomial regression
( Elsevier Inc. , 2022 , Article)Objectives: In a recent paper we suggest that the relative risk (RR) be replaced with the odds ratio (OR) as the effect measure of choice in clinical epidemiology. In response, Chu, and colleagues raise several points that ... -
Towards a better understanding of self-management interventions in type 2 diabetes: A concept analysis
( Elsevier Ltd , 2022 , Article)Objectives: Diabetes self-management educational (DSME) interventions can vary considerably, and it is unclear what is the operational conceptualization of the ideal delivery to individuals with type 2 diabetes (T2D). ... -
Comment on a review of methods to assess publication and other reporting biases in meta-analysis
( John Wiley and Sons Ltd , 2022 , Article)We read with interest the well-written review on the assessment of publication and other reporting biases in meta-analysis by Page et al.1 in which both funnel plots and tests for its asymmetry were described. The decision ... -
Research Methods for Zero Event Proportion Studies: The Incidence of Bleeding After Thoracentesis and Tube Thoracostomy in Patients With Uncorrected Coagulopathy
( Elsevier Inc. , 2021 , Article)In a recent meta-analysis published in CHEST (November 2021), Fong et al1 investigated the incidence of bleeding after thoracentesis and tube thoracostomy in patients with uncorrected coagulopathy. The authors used the ... -
Diagnostic accuracy of ELISA kits for measurement of rabies antibodies
( NLM (Medline) , 2021 , Article)[No abstract available] -
Core outcomes in gestational diabetes for treatment trials: The Gestational Metabolic Group treatment set
( John Wiley and Sons Inc , 2021 , Article)Aims With the rising number of outcomes being reported following gestational diabetes (GDM), the outcomes in existing studies vary widely making it challenging to compare and contrast the effectiveness of different ... -
Development and Validation of an Early Scoring System for Prediction of Disease Severity in COVID-19 Using Complete Blood Count Parameters
( Institute of Electrical and Electronics Engineers Inc. , 2021 , Article)The coronavirus disease 2019 (COVID-19) after outbreaking in Wuhan increasingly spread throughout the world. Fast, reliable, and easily accessible clinical assessment of the severity of the disease can help in allocating ... -
A review of breast cancer pathology reports in Nigeria
( ecancer Global Foundation , 2021 , Article Review)Background: Diagnosis and treatment of cancer rely heavily on imaging, histopathology and molecular information. Incomplete or missing tumour information can hinder the delivery of high-quality care in oncology practice, ... -
Towards a better understanding of self-management interventions in type 2 diabetes: A meta-regression analysis
( Elsevier Ltd , 2021 , Article)Aims: Attributes that operationally conceptualize diabetes self-management education (DSME) interventions have never been studied previously to assess their impact on relevant outcomes of interest in people with type 2 ...
