Medicine Research: المرسلات الحديثة
السجلات المعروضة 181 -- 200 من 1819
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Pharmacological strategies to bridge the gap between cancer and cardiovascular therapeutics
( Elsevier , 2025 , Article)Throughout the history of biomedical research, few endeavors have proven as formidable as the quest to defeat or overcome cancer and cardiovascular diseases (CVDs). Indeed, these twin scourges continue to distress humanity ... -
Beyond the stomach stall: Current and emerging pharmacotherapeutics for gastroparesis
( Elsevier , 2025 , Article)Gastroparesis is a gastrointestinal motility disorder characterized by delayed gastric emptying, which precipitates symptoms like nausea, vomiting, early satiety, and bloating. Diagnosis requires evidence of delayed gastric ... -
From bone sentinel to immune savant: Vitamin D and its receptor’s pharmacology
( Elsevier , 2025 , Article)The journey of vitamin D from a simple bone health nutrient to a complex immunomodulator is a testament to the evolving and dynamic nature of scientific understanding. Reflecting on the centennial of vitamin D’s discovery, ... -
Pharmacotherapeutic opportunities within the Hippo signaling pathway
( Elsevier , 2025 , Article)The Hippo pathway is a master of cellular regulation. It modulates intricate mechanisms that govern organ size, tissue homeostasis, and regeneration. Guo et al (2025) dissect the pathway’s multifaceted nature. Their article ... -
Reversing the odds: Advanced and emerging therapeutic strategies for male infertility
( Elsevier , 2025 , Article)Male infertility is a complex and multifaceted condition that has substantial consequences, highlighting the importance and necessity of viable sperm for conception. Despite all the advances in assisted reproductive ... -
Drugging dancing protein clouds: A close look at disorder-based drug design
( Elsevier , 2025 , Article)Since it was established in the late 19th century, the traditional “lock-and-key” model of protein functionality has been foundational in biochemistry, particularly with respect to protein structure and function (Fischer, ... -
Quantitative prediction of toxicological points of departure using two-stage machine learning models: A new approach methodology (NAM) for chemical risk assessment
( Elsevier , 2025 , Article)Point of departure (POD) is a concept used in risk assessment to calculate the reference dose of exposure that is likely to have no appreciable risk on health. POD can be directly utilized from no observed adverse effect ... -
New world of big data—new challenges for evidence synthesis: impact of data duplication on estimates generated by meta-analyses and the development of a framework for its identification and management
( Elsevier , 2024 , Article)ObjectivesThe aim of this study was to highlight the effects of entering duplicated or overlapping data from published studies using the same data registries into a meta-analysis, including its identification and management ... -
The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms
( Springer Nature , 2025 , Article)Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. While the incidence and mortality of CRC have decreased overall due to better screening, rates in adults under 50 have risen. CRC ... -
Comparative Radiological Outcomes of Stand-alone Cage versus Cage and Plate in Anterior Cervical Discectomy and Fusion: A Retrospective Cohort Study.
( Thieme Medical and Scientific Publishers Pvt. Ltd. , 2024 , Article)Anterior cervical discectomy and fusion (ACDF) is one of the most commonly used techniques for neural decompression in degenerative cervical radiculopathy and cervical myelopathy. Controversies regarding the superiority ... -
Outcomes of intramedullary nailing versus plate fixation for humeral shaft fractures: a retrospective cohort study
( Springer Nature , 2025 , Article)BACKGROUND: Humeral shaft fractures account for 1-3% of all bone fractures. Conservative treatment often leads to complications such as non-union and shoulder stiffness. Surgical fixation with a dynamic compression plate ... -
Corrigendum to “Toward a paradigm shift: Oral agents and injectable drugs in the future of obesity management” [Pharmacological Reviews 77 (2025) 100008]
( Elsevier , 2025 , Article)Author Amirhossein Sahebkar’s last name was spelled incorrectly in the first version of this article. It has been updated. The authors apologize for this error. -
Exploring the medicinal potential of Citrus limon var. pompia camarda var. nova: From phytochemicals to therapeutic applications
( Elsevier , 2025 , Article Review)Citrus limon var. pompia Camarda var. nova, (CLP) an endemic citrus fruit from Sardinia, is emerging as a significant source of bioactive compounds with extensive health benefits. This comprehensive review examines the ... -
Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
(2025 , Article)A hybrid pharmacophore model, based on structural motifs previously identified by our team, was employed to generate ligands that simultaneously target COX-2, 15-LOX, and PPARγ in the context of metabolic dysfunction-associated ... -
Evaluation of standards for sex estimation using measurements obtained from reconstructed computed tomography images of the femur of contemporary Black South Africans
( Springer Nature , 2025 , Article)Dimensions of the pelvic and skull bones are known to be sexually dimorphic in various population groups. The recovery of these bones is potentially beneficial in estimating the sex in forensic cases. Since both bones are ... -
Indications and clinical outcomes of percutaneous cholecystostomies in acute cholecystitis: a study from Qatar.
( BioMed Central , 2025 , Article)Acute cholecystitis (AC) is a prevalent condition in emergency departments (EDs). Standard care involves early laparoscopic cholecystectomy; however, in cases of delayed presentation, high surgical risk, or during situations ... -
Demographic characteristics and clinical and laboratory features of patients with Clostridiodes difficile infection: A retrospective study in Qatar
( Elsevier , 2025 , Article)ObjectivesClostridioides difficile infection (CDI) is one of the most common causes of diarrhea in healthcare facilities, imposing a significant burden on health-related budgets and resources worldwide. We aimed to study ... -
Recent advances in stem cell-based therapies for type 1 diabetes: A glimpse into the future.
( The Association of Basic Medical Sciences , 2025 , Article Review)Type 1 diabetes mellitus (T1DM) is a serious, chronic metabolic and autoimmune disease that affects millions globally. While insulin administration remains the most effective treatment, it is not a cure. Long-term therapies, ... -
The epidemiology of antimicrobial resistant bacterial infection in Qatar: A systematic review and meta-analysis
( Elsevier , 2025 , Article)BackgroundAntimicrobial resistance (AMR) is the current silent pandemic responsible for approximately five million deaths annually. According to the WHO, antimicrobial resistance is one of the top global public health ... -
Balancing the Scalpel and the Heart: A Neurosurgeon's Guide to Empathy
( Elsevier , 2025 , Article Review)Empathy is a basic core human characteristic, the foundation for social relationships and interpersonal attachment. In medicine, particularly in neurosurgery, empathy goes beyond the concept of clinical neutrality and ...
