Medicine Research: Recent submissions
Now showing items 881-900 of 1755
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Carbimazole-Induced Jaundice in Thyrotoxicosis: A Case Report.
( Springer , 2021 , Article)Carbimazole is a commonly used antithyroid drug in thyrotoxicosis. It is generally well tolerated, and its side effects include allergic skin reactions, gastrointestinal upset, agranulocytosis, and hepatotoxicity. Hepatitis ... -
Vasoactive pharmacologic therapy in cardiogenic shock: a critical review.
( Taylor & Francis , 2021 , Article)Cardiogenic shock (CS) is an acute complex condition leading to morbidity and mortality. Vasoactive medications, such as vasopressors and inotropes are considered the cornerstone of pharmacological treatment of CS to improve ... -
Proatherogenic sialidases and desialylated lipoproteins: 35 years of research and current state from bench to bedside
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)This review summarizes the main achievements in basic and clinical research of atheroscle-rosis. Focusing on desialylation as the first and the most important reaction of proatherogenic pathological cascade, we speak of ... -
Clinical significance of P-class pumps in cancer (Review)
( Spandidos Publications , 2021 , Article)P-class pumps are specific ion transporters involved in maintaining intracellular/extracellular ion homeostasis, gene transcription, and cell proliferation and migration in all eukaryotic cells. The present review aimed ... -
Hyperosmotic Stress Induces a Specific Pattern for Stress Granule Formation in Human-Induced Pluripotent Stem Cells
( Hindawi , 2021 , Article)Stress granules (SGs) are assemblies of selective messenger RNAs (mRNAs), translation factors, and RNA-binding proteins in small untranslated messenger ribonucleoprotein (mRNP) complexes in the cytoplasm. Evidence indicates ... -
Beta-caryophyllene exhibits anti-proliferative effects through apoptosis induction and cell cycle modulation in multiple myeloma cells
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Cannabinoid receptors, which are widely distributed in the body, have been considered as possible pharmacological targets for the management of several tumors. Cannabinoid type 2 receptors (CB2Rs) belong to the G protein-coupled ... -
Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome
( Frontiers Media S.A. , 2021 , Article)Background: Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase ... -
Atrial fibrillation in Middle Eastern Arabs and South Asians: a scoping review
( IMR Press Limited , 2021 , Article)Most of the published literature on Atrial fibrillation (AF) originates from the northern hemisphere and mainly involves Caucasian patients, with limited studies in certain ethnicities and races. This scoping review was ... -
Risk of Depression and Suicide in Diabetic Patients.
( Springer , 2022 , Article)Although mental disorders in diabetics are more prevalent than in the general population, an increased prevalence of depression, frequently leading to suicide, has been reported in individuals with diabetes mellitus. ... -
Gas Under Diaphragm: A Rare Case of Ruptured Liver Abscess With Gas Forming Organism.
( Springer , 2022 , Article)Acute abdominal pain with free air under the diaphragm visible on chest/abdomen X-ray (pneumoperitoneum) is a medical emergency. Most of such cases of pneumoperitoneum are attributable to perforated hollow viscus; however, ... -
Editorial: Methods and application in cardiovascular and smooth muscle pharmacology: 2021
( Frontiers Media S.A. , 2022 , Article)Despite significant advances in basic, translational, and clinical research tackling heart disease, cardiovascular pathologies remain among the leading causes of mortality and morbidity worldwide, being responsible for ... -
Modulation of Neuro-Inflammatory Signals in Microglia by Plasma Prekallikrein and Neuronal Cell Debris
( Frontiers Media , 2021 , Article)Microglia, the resident phagocytes of the central nervous system and one of the key modulators of the innate immune system, have been shown to play a major role in brain insults. Upon activation in response to neuroinflammation, ... -
The Exposure to Human Breast Cancer Cells Altered 14 Post-Translational Modifications of Human Serum Albumin.
( International Federation of Clinical Chemistry and Laboratory Medicine , 2022 , Article)Serum albumin is in contact with practically all cells in the human body, including tumor cells in cancer patients. The purpose of this study was to explore whether cancer cells affect post-translational modifications ... -
The Effects of Statin Treatment on Serum Ferritin Levels: A Systematic Review and Meta-Analysis
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Background: Statins are the most widely used drugs for decreasing elevated serum LDL-cholesterol (LDL-C) and thus for the prevention of atherosclerotic cardiovascular disease (ASCVD), but they have also some pleiotropic ... -
Direct oral anticoagulants in patients with nonvalvular atrial fibrillation and extreme body weight
( Wiley-Blackwell , 2022 , Article)Bodega et al.'s recent report on the efficacy and safety of direct oral anticoagulants (DOACs) in patients with nonvalvular atrial fibrillation and extreme body weight reinforces recent therapeutics advances in anticoagulation ... -
Prevalence and Determinants of Mental Health Problems and Mental Health Stigma Among Medical Students of Different Nationalities in Qatar
( Dove Medical Press , 2022 , Article)Introduction: Past studies have shown high prevalence of mental illness among medical students. This is often linked to the demands of the medical curriculum, and to mental health stigma that prevents students from seeking ... -
The determination of causality of drug induced liver injury in patients with COVID-19 clinical syndrome
( Public Library of Science , 2022 , Article)Background Drug induced liver injury (DILI) is a rising morbidity amongst patients with COVID-19 clinical syndrome. The updated RUCAM causality assessment scale is validated for use in the general population, but its utility ... -
Platelet thromboxane inhibition by low-dose aspirin in polycythemia vera: Ex vivo and in vivo measurements and in silico simulation
( Wiley , 2022 , Article)Low-dose aspirin is currently recommended for patients with polycythemia vera (PV), a myeloproliferative neoplasm with increased risk of arterial and venous thromboses. Based on aspirin pharmacodynamics in essential ... -
Home Cancer Care Research: A Bibliometric and Visualization Analysis (1990–2021)
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Home cancer care research (HCCR) has accelerated, as considerable attention has been placed on reducing cancer-related health costs and enhancing cancer patients’ quality of life. Understanding the current status of HCCR ... -
Critical care tele-pharmacy services during COVID-19 pandemic: A qualitative exploration of healthcare practitioners' perceptions
( Wiley-Blackwell , 2022 , Article)What is Known and Objective: The scope of clinical pharmacy services has changed during COVID-19 pandemic with the view to mitigating both exposure and spread of the virus. The performance of novel pandemic-driven services ...
