Browsing Pharmacy Research by Author "Agouni, Abdelali"
Now showing items 1-6 of 6
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Comparison of the Protective Effects of Individual Components of Particulated trans-Sialidase (PTCTS), PTC and TS, against High Cholesterol Diet-Induced Atherosclerosis in Rabbits
Garavelo, Shérrira M; Higuchi, Maria de Lourdes; Pereira, Jaqueline J; Reis, Marcia M; Kawakami, Joyce T; Ikegami, Renata N; Palomino, Suely AP; Wadt, Nilsa S Y; Agouni, Abdelali... more authors ... less authors ( Hindawi Publishing Corporation , 2017 , Article)Previous studies showed the presence of Mycoplasma pneumoniae (M. pneumoniae) and membrane-shed microparticles (MPs) in vulnerable atherosclerotic plaques. H&S Science and Biotechnology developed PTCTS, composed by natural ... -
In Vitro and In Vivo Validation of GATA-3 Suppression for Induction of Adipogenesis and Improving Insulin Sensitivity
Al-Jaber, Hend; Mohamed, Nura A.; Govindharajan, Vijay K.; Taha, Samir; John, Jomon; Halim, Sharique; Alser, Maha; Al-Muraikhy, Shamma; Anwardeen, Najeha Rizwana; Agouni, Abdelali; Elhissi, Abdelbary; Al-Naemi, Hamda A.; Al-Mansoori, Layla; Elrayess, Mohamed A.... more authors ... less authors ( MDPI , 2022 , Article)Impaired adipogenesis is associated with the development of insulin resistance and an increased risk of type 2 diabetes (T2D). GATA Binding Protein 3 (GATA3) is implicated in impaired adipogenesis and the onset of insulin ... -
Interplay between Endoplasmic Reticulum Stress and Large Extracellular Vesicles (Microparticles) in Endothelial Cell Dysfunction
Osman, Aisha; Benameur, Tarek; Korashy, Hesham M.; Zeidan, Asad; Agouni, Abdelali ( MDPI , 2020 , Article)Upon increased demand for protein synthesis, accumulation of misfolded and/or unfolded proteins within the endoplasmic reticulum (ER), a pro-survival response is activated termed unfolded protein response (UPR), aiming at ... -
Oral PTCTS (Particulated Transialidase) Removes Serum Microparticles and Decreases Inflammation in Atherosclerotic Plaques of Rabbits
Garavelo, Sherrira M.; Pereira, Jacqueline J.; Wadt, Nilsa S.Y.; Reis, Marcia M.; Ikegami, Renata N.; Kawakami, Joyce T.; Agouni, Abdelali; Palomino, Suely A.P.; Abdalla, Dulcineia; Higuchi, Maria de Lourdes... more authors ... less authors ( Scientific Research Publishing , 2015 , Article)Background: Previous studies showed that atherosclerotic plaque vulnerability was related with microparticles (MPs)-vesicles larger than 100 nm, which released MMP9 collagenase. In our pre- vious study, intramuscular ... -
Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress-impaired endothelial cell angiogenic response: A critical role for cell survival
ABDELSALAM, SHAHENDA S.; PASHA, MAZHAR; EL-GAMAL, HEBA; HASAN, MARAM; ELRAYESS, MOHAMED A.; ZEIDAN, ASAD; KORASHY, HESHAM M.; AGOUNI, ABDELALI... more authors ... less authors ( Spandidos publications , 2021 , Article)Endoplasmic reticulum (ER) stress contributes to endothelial dysfunction, which is the initial step in atherogenesis. Blockade of protein tyrosine phosphatase (PTP)1B, a negative regulator of insulin receptors that is ... -
Temporal cross talk between endoplasmic reticulum and mitochondria regulates oxidative stress and mediates microparticle-induced endothelial dysfunction
Safiedeen, Zainab; Rodríguez-Gómez, Isabel; Vergori, Luisa; Soleti, Raffaella; Vaithilingam, Dayannath; Douma, Imene; Agouni, Abdelali; Leiber, Denis; Dubois, Séverine; Simard, Gilles; Zibara, Kazem; Andriantsitohaina, Ramaroson; Martínez, M. Carmen... more authors ... less authors ( Mary Ann Liebert, Inc. , 2017 , Article)Aims: Circulating microparticles (MPs) from metabolic syndrome patients and those generated from apoptotic T-cells induce endothelial dysfunction; however, the molecular and cellular mechanism(s) underlying in the effects ...