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Cost-effectiveness Evaluations Among the Direct Oral Anticoagulants for the Prevention and Treatment of Venous Thromboembolism: Systematic Review
(
SAGE Publications Inc.
, 2019 , Article)
Venous thromboembolism (VTE) is associated with high recurrence, mortality, and cost burden. Direct oral anticoagulants (DOACs) are currently used for VTE treatment, and they offer more benefits over warfarin, despite being ...
Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines.
(
MDPI
, 2019 , Article)
Clear cell renal cell carcinoma (ccRCC) is the most common and lethal form of urological cancer diagnosed globally. Mutations of the von Hippel-Lindau tumor-suppressor gene and the resultant overexpression of hypoxia-inducible ...
Pharmacy academics' perspectives toward interprofessional Education prior to its implementation in Qatar: a qualitative study
(
NLM (Medline)
, 2019 , Article)
BACKGROUND: The aim of this study was to explore the perspectives of faculty members and academic administrators, at Qatar University College of Pharmacy, towards interprofessional education (IPE) and collaborative practice ...
The role of NF-κB and AhR transcription factors in lead-induced lung toxicity in human lung cancer A549 cells.
(
Taylor & Francis
, 2019 , Article)
Lead (Pb) is recognized as the first heavy metal of the top six toxic air pollutants threatening human health and the second hazardous substance. Pb exposure is associated with lung impairment and high incidences of lung ...
CD56 expression in breast cancer induces sensitivity to natural killer-mediated cytotoxicity by enhancing the formation of cytotoxic immunological synapse
(
Nature Publishing Group
, 2019 , Article)
We examined the potential value of the natural killer (NK) cell line; NK-92, as immunotherapy tool for breast cancer (BC) treatment and searched for biomarker(s) of sensitivity to NK-92-mediated cytotoxicity. The cytotoxic ...
Administration error of benzathine penicillin G in a Saudi male
(
Wiley-Blackwell
, 2019 , Article)
Background
Benzathine penicillin G is indicated for intramuscular (IM ) administration. There have been reports of unintentional intravenous (IV ) administration, which has been associated with cardiorespiratory arrest ...
Greensporone A, a fungal secondary metabolite suppressed constitutively activated AKT via ROS generation and induced apoptosis in leukemic cell lines
(
MDPI AG
, 2019 , Article)
Greensporone A is a fungal secondary metabolite that has exhibited potential in vitro for anti-proliferative activity in vitro. We studied the anticancer activity of greensporone A in a panel of leukemic cell lines. ...
Na + /H + exchanger isoform 1-induced osteopontin expression facilitates cardiac hypertrophy through p90 ribosomal S6 kinase
(
NLM (Medline)
, 2018 , Article)
Cardiovascular diseases are the leading cause of death worldwide. One in three cases of heart failure is due to dilated cardiomyopathy. The Na+/H+ exchanger isoform 1 (NHE1), a multifunctional protein and the key pH regulator ...
Setting the agenda for clinical pharmacy in Qatar: thematic and content analyses of news media headlines
(
Centro de Investigaciones y Publicaciones Farmaceuticas
, 2019 , Article)
Public awareness of the role of pharmacists and availability of pharmacy services in Qatar is low. As per agenda-setting theory, mass media may be contributing toward this problem by selecting and disseminating headlines ...
Development of injectable PEGylated liposome encapsulating disulfiram for colorectal cancer treatment
(
MDPI AG
, 2019 , Article)
Disulfiram (DS), an anti-alcoholism medicine, shows strong anti-cancer activity in the laboratory, but the application in clinics for anti-cancer therapy has been limited by its prompt metabolism. Conventional liposomes ...