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Pharmaceutical pricing policies in Qatar and Lebanon: narrative review and document analysis
(
Blackwell Publishing Ltd
, 2019 , Article Review)
Objectives: This study aimed at reviewing and analysing the pharmaceutical pricing policies implemented in two middle-east countries. Methods: Official documents related to national pharmaceutical pricing policies were ...
7-O-methylpunctatin, a novel homoisoflavonoid, inhibits phenotypic switch of human arteriolar smooth muscle cells
(
MDPI AG
, 2019 , Article)
Remodeling of arterioles is a pivotal event in the manifestation of many inflammation-based cardio-vasculopathologies, such as hypertension. During these remodeling events, vascular smooth muscle cells (VSMCs) switch from ...
Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1-mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma
(
BioMed Central Ltd.
, 2019 , Article)
Background: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Phloretin (PH) possesses anticancer, antitumor, and hepatoprotective effects, however, the effects and potential mechanisms of phloretin ...
Ibrutinib-associated sever skin toxicity: A case of multiple inflamed skin lesions and cellulitis in a 68-year-old male patient with relapsed chronic lymphocytic leukemia Case report and literature review
(
SAGE Publications Ltd
, 2019 , Article)
Introduction: Ibrutinib is an oral inhibitor of Bruton's tyrosine kinase that is used for a variety of B cell hematological malignancies. Skin and subcutaneous tissue manifestations have been reported and were witnessed ...
There Is Selective Increase in Pro-thrombotic Circulating Extracellular Vesicles in Acute Ischemic Stroke and Transient Ischemic Attack: A Study of Patients From the Middle East and Southeast Asia.
(
Frontiers Media
, 2019 , Article)
Stroke attacks were found to be present at a younger age in patients from Southeast Asia (SE) and the Middle East (ME) resident in the state of Qatar. Extracellular vesicles (EVs), which are small membrane vesicles with ...
Optimizing assessors’ mental workload in rater-based assessment: a critical narrative review
(
Bohn Stafleu van Loghum
, 2019 , Article Review)
Introduction
Rater-based assessment has resulted in high cognitive demands for assessors within the education of health professionals. Rating quality may be influenced by the mental workload required of assessors to ...
Selenium and Health: An Update on the Situation in the Middle East and North Africa.
(
MDPI
, 2019 , Article)
Selenium (Se) is an important trace element that should be present in the diet of all age groups to provide an adequate intake. Se is incorporated in 25 known selenoproteins, which mediate the biological effects of Se ...
Circulating microparticles as biomarkers of stroke: A focus on the value of endothelial- and platelet-derived microparticles.
(
Wiley
, 2019 , Article)
Stroke is one of the leading causes of mortality and disability worldwide. Numerous pathophysiological mechanisms involving blood vessels, coagulation and inflammation contribute to the vascular occlusion. Perturbations ...
Clinical and Pharmacokinetic Outcomes of Peak–Trough-Based Versus Trough-Based Vancomycin Therapeutic Drug Monitoring Approaches: A Pragmatic Randomized Controlled Trial
(
Springer-Verlag France
, 2019 , Article)
Background
Vancomycin therapeutic drug monitoring (TDM) is based on achieving 24-h area under the concentration–time curve to minimum inhibitory concentration cure breakpoints (AUC24/MIC). Approaches to vancomycin TDM ...
Tobacco Use among Adult Muslims in the United States.
(
Taylor & Francis
, 2019 , Article)
Compared with the general United States (US) population, Muslims in the US exhibit elevated rates of tobacco use. As a result, they might be at a higher risk for preventive disease and premature death as compared with the ...