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A novel approach of encapsulating curcumin and succinylated derivative in mannosylated-chitosan nanoparticles
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Elsevier
, 2022 , Article)
Curcumin (CUR) manifests anti-colon cancer activity but suffers from low solubility, bioavailability, and instability, rendering it not as effective as its chemotherapeutic cousins. Here, we conjugate CUR to succinic ...
Crosstalk between aryl hydrocarbon receptor (AhR) and BCL-2 pathways suggests the use of AhR antagonist to maintain normal differentiation state of mammary epithelial cells during BCL-2 inhibition therapy
(
Elsevier
, 2022 , Article)
IntroductionActivating the aryl hydrocarbon receptor upon exposure to environmental pollutants promotes development of breast cancer stem cell (CSCs). BCL-2 family proteins protect cancer cells from the apoptotic effects ...
Correction to: Lead nitrate induces inflammation and apoptosis in rat lungs through the activation of NF‑κB and AhR signaling pathways (Environmental Science and Pollution Research, (2022), 29, 43, (64959-64970), 10.1007/s11356-022-19980-8)
(
Springer
, 2022 , Article)
The sizing of images Figs. 3 and 4 is modified in the original published proof. The Original article has been corrected.
Analysis of fatalities involving amphetamine in Jazan, Saudi Arabia
(
Elsevier
, 2021 , Article)
Amphetamine use is associated with high tendence of homicidal or suicidal deaths and fatalities making amphetamine a persistent area of concern. This study analyzed fatalities associated with amphetamine use in Jazan city, ...
Lead Nitrate Induces Inflammation and Apoptosis in Rat Lungs Through the Activation of NF-κB and AhR Signaling Pathways
(
Springer
, 2022 , Article)
Lead (Pb) is one of the most frequent hazardous air contaminants, where the lungs are particularly vulnerable to its toxicity. However, the Pb distribution and its impact on lung inflammation/apoptosis and particularly the ...
Role of RAS signaling in ovarian cancer
(
Taylor & Francis
, 2022 , Article)
The RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS, especially KRAS mutational status at codons 12, 13, and ...
Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress-impaired endothelial cell angiogenic response: A critical role for cell survival
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Spandidos publications
, 2021 , Article)
Endoplasmic reticulum (ER) stress contributes to endothelial dysfunction, which is the initial step in atherogenesis. Blockade of protein tyrosine phosphatase (PTP)1B, a negative regulator of insulin receptors that is ...
Cathine and cathinone disposition kinetics and neurotransmitter profile in several organs of rats exposed to a single dose of Catha edulis (Vahl) Forssk. ex Endl. extract
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Walter de Gruyter
, 2023 , Article)
Catha edulis (Vahl) Forssk. ex Endl. (Khat) is a stimulant plant that contains cathine and cathinone, which its abuses induce euphoria, alertness, and motor activity. Since the toxicokinetics of these substances remain ...
6-Formylindolo(3,2-b)carbazole Dampens Inflammation and Reduces Endotoxin-Induced Kidney Injury via Nrf2 Activation
(
American Chemical Society (ACS)
, 2023 , Article)
Patients with sepsis are at a high risk of morbidity and mortality due to multiple organ injuries caused by pathological inflammation. Although sepsis is accompanied by multiple organ injuries, acute renal injury is a ...
Interplay between Endoplasmic Reticulum Stress and Large Extracellular Vesicles (Microparticles) in Endothelial Cell Dysfunction
(
MDPI
, 2020 , Article)
Upon increased demand for protein synthesis, accumulation of misfolded and/or unfolded proteins within the endoplasmic reticulum (ER), a pro-survival response is activated termed unfolded protein response (UPR), aiming at ...