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    Metformin Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro 

    Allouch, Soumaya; Munusamy, Shankar ( Wiley Periodicals, Inc , 2017 , Article)
    Proteinuria (albuminuria) plays a crucial role in the etiology of chronic kidney disease (CKD) via alteration of multiple signaling pathways and cellular process in renal cells. The objectives of this study are to investigate ...
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    Structure–activity relationship of piperine and its synthetic amide analogs for therapeutic potential to prevent experimentally induced ER stress in vitro 

    Hammad, Ayat S.; Ravindran, Sreenithya; Khalil, Ashraf; Munusamy, Shankar ( Springer Netherlands , 2017 , Article)
    Endoplasmic reticulum (ER) is the key organelle involved in protein folding and maturation. Emerging studies implicate the role of ER stress in the development of chronic kidney disease. Thus, there is an urgent need for ...
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    Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury 

    El Gamal, Heba; Eid, Ali Hussein; Munusamy, Shankar ( Hindawi , 2017 , Article)
    Diabetic nephropathy (DN) is the leading cause of end stage renal disease worldwide. Increased glucose flux into the aldose reductase (AR) pathway during diabetes was reported to exert deleterious effects on the kidney. ...
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    Obesity-induced changes in kidney mitochondria and endoplasmic reticulum in the presence or absence of leptin 

    Munusamy, Shankar; do Carmo, Jussara M.; Hosler, Jonathan P.; Hall, John E. ( American Physiological Society , 2015 , Article)
    We investigated obesity-induced changes in kidney lipid accumulation, mitochondrial function, and endoplasmic reticulum (ER) stress in the absence of hypertension, and the potential role of leptin in modulating these ...
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    Aldose Reductase as a Drug Target for Treatment of Diabetic Nephropathy: Promises and Challenges. 

    El Gamal, Heba; Munusamy, Shankar ( Bentham Science Publishers , 2017 , Article)
    Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes mellitus and the leading cause of end stage renal disease. One of the key pathways activated in DN is the polyol pathway, in which ...
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    Nephroprotective Effects of Metformin in Diabetic Nephropathy 

    Ravindran, Sreenithya; Kuruvilla, Vinitha; Wilbur, Kerry; Munusamy, Shankar ( Wiley , 2017 , Article)
    Metformin, a well-known anti-diabetic agent, is very effective in lowering blood glucose in patients with type 2 diabetes with minimal side-effects. Metformin is also being recommended in the treatment of obesity and ...
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    Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines. 

    Pasha, Mazhar; Sivaraman, Siveen K; Frantz, Ronald; Agouni, Abdelali; Munusamy, Shankar ( MDPI , 2019 , Article)
    Clear cell renal cell carcinoma (ccRCC) is the most common and lethal form of urological cancer diagnosed globally. Mutations of the von Hippel-Lindau tumor-suppressor gene and the resultant overexpression of hypoxia-inducible ...
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    Molecular Mechanisms Underpinning Microparticle-Mediated Cellular Injury in Cardiovascular Complications Associated with Diabetes. 

    Benameur, Tarek; Osman, Aisha; Parray, Aijaz; Ait Hssain, Ali; Munusamy, Shankar; Agouni, Abdelali... more authors ... less authors ( Hindawi , 2019 , Article)
    Microparticles (MPs) are small vesicles shed from the cytoplasmic membrane of healthy, activated, or apoptotic cells. MPs are very heterogeneous in size (100-1,000 nm), and they harbor proteins and surface antigens specific ...
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    The use of Socrative and Yammer online tools to promote interactive learning in pharmacy education 

    Munusamy, Shankar; Osman, Aisha; Riaz, Sadaf; Ali, Shaima; Mraiche, Fatima ( Elsevier Inc. , 2019 , Article)
    Background and purpose Engagement of students in the didactic classroom setting restricts students’ time spent towards active learning, which in turn, adversely affects the retention of concepts taught through traditional ...
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    Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases 

    Pasha, Mazhar; Eid, Ali H.; Eid, Assaad A.; Gorin, Yves; Munusamy, Shankar ( Hindawi , 2017 , Article)
    Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative stress, ...
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      Munusamy, Shankar (7)
    • Munusamy, Shankar (5)
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