عرض بسيط للتسجيلة

المؤلفTedy, Sawma
المؤلفShaito, Abdullah
المؤلفNajm, Nicolas
المؤلفSidani, Munir
المؤلفOrekhov, Alexander
المؤلفEl-Yazbi, Ahmed F.
المؤلفIratni, Rabah
المؤلفEid, Ali H.
تاريخ الإتاحة2022-09-06T05:26:25Z
تاريخ النشر2022-10-31
اسم المنشورAtherosclerosis
المعرّفhttp://dx.doi.org/10.1016/j.atherosclerosis.2022.08.012
الاقتباسSawma T, Shaito A, Najm N, Sidani M, Orekhov A, El-Yazbi AF, Iratni R, Eid AH. Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function. Atherosclerosis. 2022 Aug 15;358:12-28. doi: 10.1016/j.atherosclerosis.2022.08.012.
الرقم المعياري الدولي للكتاب00219150
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S0021915022013958
معرّف المصادر الموحدhttp://hdl.handle.net/10576/33698
الملخصCardiovascular disease (CVD) continues to be the primary cause of global mortality. Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and function, evident by their vital roles in modulating blood flow and pressure. Such roles exist due to the differentiated contractile phenotype of VSMCs. However, VSMCs may switch to a dedifferentiated, proliferative synthetic phenotype in a phenomenon known as phenotypic switching. This switch involves dramatic changes in VSMC migration, proliferation, gene expression programs, differentiation, cellular stiffness and extracellular matrix (ECM) deposition. In this review, we explore the role of the small GTPase Rho and its effector, Rho-associated kinase (ROCK), in phenotypic switching as well as apoptotic pathways in VSMCs. We critically dissect how RhoA promotes cell migration and proliferation as well as its role in modulating the expression of a battery of VSMC marker proteins. We also discuss how RhoA modulates apoptosis, induces dedifferentiation, increases vascular stiffness, or modifies ECM accumulation. These alterations in VSMC phenotypes contribute to multiple vascular dysfunctions, including hypertension and atherosclerosis. Understanding the molecular underpinnings and the signaling pathways involved in these altered phenotypes may provide novel avenues of drug design and other therapeutic interventions for the management of CVDs.
اللغةen
الناشرElsevier
الموضوعRhoA
Rho kinase
Vascular smooth muscle cell
Phenotypic switch
Cardiovascular disease
Apoptosis
العنوانRole of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function
النوعArticle Review
الصفحات12-28
رقم المجلد358
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة