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Salinomycin induces apoptosis and senescence in breast cancer: Upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation
(
Elsevier
, 2013 , Article)
Background
In the present study, we investigated the effect of Salinomycin on the survival of three human breast cancer cell lines MCF-7, T47D and MDA-MB-231 grown in adherent culture conditions.
Methods
Cell viability ...
Mechanisms underlying the antihypertensive effects of garlic bioactives
(
Elsevier Inc.
, 2014 , Article)
Cardiovascular disease remains the leading cause of death worldwide with hypertension being a major contributing factor to cardiovascular disease–associated mortality. On a population level, non-pharmacological approaches, ...
Cyclic AMP-Rap1A signaling mediates cell surface translocation of microvascular smooth muscle α2C-adrenoceptors through the actin-binding protein filamin-2
(
American Physiological Society
, 2013 , Article)
The second messenger cyclic AMP (cAMP) plays a vital role in vascular physiology, including vasodilation of large blood vessels. We recently demonstrated cAMP activation of Epac-Rap1A and RhoA-Rho-associated kinase ...
Cyclic AMP-Rap1A signaling activates RhoA to induce α2c-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells
(
American Physiological Society
, 2012 , Article)
Intracellular signaling by the second messenger cyclic AMP (cAMP) activates the Ras-related small GTPase Rap1 through the guanine exchange factor Epac. This activation leads to effector protein interactions, activation, ...
CAMP induces adhesion of microvascular smooth muscle cells to fibronectin via an epac-mediated but PKA-independent mechanism
(
Cell Physiol Biochem Press
, 2012 , Article)
Background/Aims: Vascular smooth muscle cells (VSMCs) play important roles, both in physiologic and pathophysiologic processes. Adhesion of these cells is critical for their proper functioning, especially in resistance-sized ...
Early stage litter decomposition across biomes
(
Elsevier B.V.
, 2018 , Article)
© 2018 Elsevier B.V. Through litter decomposition enormous amounts of carbon is emitted to the atmosphere. Numerous large-scale decomposition experiments have been conducted focusing on this fundamental soil process in ...
Effect of temperature on the growth, survival, development and foraging behaviour of Sardina pilchardus larvae
(
Inter-Research
, 2016 , Article)
The effect of water temperature on the growth, survival, development and foragin behaviour of European sardine Sardina pilchardus larvae was examined in the laboratory. First the capability of early sardine larvae to cope ...
Benthic marine algae of the arabian gulf: A critical review and analysis of distribution and diversity patterns
(
Schweizerbart Science Publishers
, 2014 , Article)
The Arabian Gulf is an extremely inhospitable and physiologically-stressful environment for marine organisms since they are exposed to the widest range and the highest sea temperatures in the world, as well as high salinities. ...
Determination of vascular reactivity of middle cerebral arteries from stroke and spinal cord injury animal models using pressure myography
(
Humana Press Inc.
, 2016 , Book chapter)
Stroke and other neurovascular derangements are main causes of global death. They, along with spinal cord injuries, are responsible for being the principal cause of disability due to neurological and cognitive problems. ...
Halophytes as important sources of antioxidants and anti-cholinesterase compounds
(
Springer International Publishing
, 2021 , Book chapter)
Halophytes are plants adapted to high salinity, and they are common in many places around the world where environmental conditions are inconvenient for the growth of conventional plants. Normally, plants exposed to harsh ...