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Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases
(
Hindawi
, 2017 , Article)
Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative stress, ...
Colorectal and Prostate Cancer Risk in Diabetes: Metformin, an Actor behind the Scene
(
Ivyspring International Publisher
, 2014 , Article)
Both diabetes and cancer are prevalent diseases whose incidence rates are increasing worldwide, especially in countries that are undergoing rapid industrialization changes. Apparently, lifestyle risk factors including diet, ...
Anti-hypertensive Herbs and their Mechanisms of Action: Part I
(
Frontiers Media
, 2016 , Article)
The use of herbal therapies for treatment and management of cardiovascular diseases (CVDs) is increasing. Plants contain a bounty of phytochemicals that have proven to be protective by reducing the risk of various ailments ...
Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II
(
Frontiers Media
, 2016 , Article)
Traditional medicine has a history extending back to thousands of years, and during the intervening time, man has identified the healing properties of a very broad range of plants. Globally, the use of herbal therapies to ...
Inflammogenesis of Secondary Spinal Cord Injury
(
Frontiers Media
, 2016 , Article)
Spinal cord injury (SCI) and spinal infarction lead to neurological complications and eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major contributors to morbidity. Our understanding ...
Anti-atherosclerotic plants which modulate the phenotype of vascular smooth muscle cells
(
Elsevier
, 2016 , Article)
Background: Cardiovascular disease (CVD) remains the leading cause of global death, with atherosclerosis being a major contributor to this mortality. Several mechanisms are implicated in the pathogenesis of this disease. ...
Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival.
(
MDPI
, 2019 , Article)
Dietary intake of natural antioxidants is thought to impart protection against oxidative-associated cardiovascular diseases. Despite many in vivo studies and clinical trials, this issue has not been conclusively resolved. ...
Salvia fruticosa Induces Vasorelaxation in Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway
(
Nature Publishing Group
, 2017 , Article)
Salvia fruticosa (SF) Mill. is traditionally used for its antihypertensive actions. However, little is known about its pharmacologic and molecular mechanisms of action. Here we determined the effects of an ethanolic extract ...
Glucocorticoid-induced fetal origins of adult hypertension: Association with epigenetic events
(
Elsevier Inc.
, 2016 , Article Review)
Hypertension is a predominant risk factor for cardiovascular diseases and a major health care burden. Accumulating epidemiological and experimental evidence suggest that adult-onset hypertension may have its origins during ...
Inositol 1,4,5-Trisphosphate Receptors in Hypertension.
(
Frontiers Media
, 2018 , Article Review)
Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. ...