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    SARS-CoV-2 modulates virus receptor expression in placenta and can induce trophoblast fusion, inflammation and endothelial permeability

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    SARS-CoV2 placenta (26.23Mb)
    Date
    2022-09-13
    Author
    Agostinis, Chiara
    Toffoli, Miriam
    Spazzapan, Mariagiulia
    Balduit, Andrea
    Zito, Gabriella
    Mangogna, Alessandro
    Zupin, Luisa
    Salviato, Tiziana
    Maiocchi, Serena
    Romano, Federico
    Crovella, Sergio
    Fontana, Francesco
    Braga, Luca
    Confalonieri, Marco
    Ricci, Giuseppe
    Kishore, Uday
    Bulla, Roberta
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    Abstract
    SARS-CoV-2 is a devastating virus that induces a range of immunopathological mechanisms including cytokine storm, apoptosis, inflammation and complement and coagulation pathway hyperactivation. However, how the infection impacts pregnant mothers is still being worked out due to evidence of vertical transmission of the SARS-CoV-2, and higher incidence of pre-eclampsia, preterm birth, caesarian section, and fetal mortality. In this study, we assessed the levels of the three main receptors of SARS-CoV-2 (ACE2, TMPRSS2 and CD147) in placentae derived from SARS-CoV-2 positive and negative mothers. Moreover, we measured the effects of Spike protein on placental cell lines, in addition to their susceptibility to infection. SARS-CoV-2 negative placentae showed elevated levels of CD147 and considerably low amount of TMPRSS2, making them non-permissive to infection. SARS-CoV-2 presence upregulated TMPRSS2 expression in syncytiotrophoblast and cytotrophoblast cells, thereby rendering them amenable to infection. The non-permissiveness of placental cells can be due to their less fusogenicity due to infection. We also found that Spike protein was capable of inducing pro-inflammatory cytokine production, syncytiotrophoblast apoptosis and increased vascular permeability. These events can elicit pre-eclampsia-like syndrome that marks a high percentage of pregnancies when mothers are infected with SARS-CoV-2. Our study raises important points relevant to SARS-CoV-2 mediated adverse pregnancy outcomes.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85138867288&origin=inward
    DOI/handle
    http://dx.doi.org/10.3389/fimmu.2022.957224
    http://hdl.handle.net/10576/35352
    Collections
    • Biological & Environmental Sciences [‎932‎ items ]
    • COVID-19 Research [‎849‎ items ]

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