Show simple item record

AuthorNaeem, Aisha
AuthorGupta, Nikita
AuthorNaeem, Usra
AuthorElrayess, Mohamed A.
AuthorAlbanese, Chris
Available date2022-10-29T13:29:20Z
Publication Date2022-01-01
Publication NameHuman Cell
Identifierhttp://dx.doi.org/10.1007/s13577-022-00795-1
CitationNaeem, A., Gupta, N., Naeem, U. et al. Amniotic stem cells as a source of regenerative medicine to treat female infertility. Human Cell (2022). https://doi.org/10.1007/s13577-022-00795-1
ISSN09147470
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85140092907&origin=inward
URIhttp://hdl.handle.net/10576/35564
AbstractImpaired reproductive health is a worldwide problem that affects the psychological well-being of a society. Despite the technological developments to treat infertility, the global infertility rate is increasing significantly. Many infertility conditions are currently treated using various advanced clinical approaches such as intrauterine semination (IUI), in vitro fertilization (IVF), and intracytoplasmic injection (ICSI). Nonetheless, clinical management of some conditions such as dysfunctional endometrium, premature ovarian failure, and ovarian physiological aging still pose significant challenges. Stem cells based therapeutic strategies have a long-standing history to treat many infertility conditions, but ethical restrictions do not allow the broad-scale utilization of adult mesenchymal stromal/stem cells (MSCs). Easily accessible, placental derived or amniotic stem cells present an invaluable alternative source of non-immunogenic and non-tumorigenic stem cells that possess multilineage potential. Given these characteristics, placental or amniotic stem cells (ASCs) have been investigated for therapeutic purposes to address infertility in the last decade. This study aims to summarize the current standing and progress of human amniotic epithelial stem cells (hAECs), amniotic mesenchymal stem cells (hAMSCs), and amniotic fluid stem cells (hAFSCs) in the field of reproductive medicine. The therapeutic potential of these cells to restore or enhance normal ovarian function and pregnancy outcomes are highlighted in this study.
SponsorOpen Access funding provided by the Qatar National Library. The authors reported there is no funding associated with the work featured in this article.
Languageen
PublisherSpringer
SubjectAmniotic stem cells
Endometrium
Infertility
Ovarian failure
Ovarian physiological aging
TitleAmniotic stem cells as a source of regenerative medicine to treat female infertility
TypeArticle Review
ESSN1749-0774
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record