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    Optimization of Anti-SARS-CoV-2 Treatments Based on Curcumin, Used Alone or Employed as a Photosensitizer.

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    SARS-CoV2 curcumin (23.40Mb)
    Date
    2022-09-27
    Author
    Zupin, Luisa
    Fontana, Francesco
    Clemente, Libera
    Borelli, Violetta
    Ricci, Giuseppe
    Ruscio, Maurizio
    Crovella, Sergio
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    Abstract
    Curcumin, the bioactive compound of the spice , has already been reported as a potential COVID-19 adjuvant treatment due to its immunomodulatory and anti-inflammatory properties. In this study, SARS-CoV-2 was challenged with curcumin; moreover, curcumin was also coupled with laser light at 445 nm in a photodynamic therapy approach. Curcumin at a concentration of 10 μM, delivered to the virus prior to inoculation on cell culture, inhibited SARS-CoV-2 replication (reduction >99%) in Vero E6 cells, possibly due to disruption of the virion structure, as observed using the RNase protection assay. However, curcumin was not effective as a prophylactic treatment on already-infected Vero E6 cells. Notably, when curcumin was employed as a photosensitizer and blue laser light at 445 nm was delivered to a mix of curcumin/virus prior to the inoculation on the cells, virus inactivation was observed (>99%) using doses of curcumin that were not antiviral by themselves. Photodynamic therapy employing crude curcumin can be suggested as an antiviral option against SARS-CoV-2 infection.
    DOI/handle
    http://dx.doi.org/10.3390/v14102132
    http://hdl.handle.net/10576/35719
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    • Biological & Environmental Sciences [‎932‎ items ]
    • COVID-19 Research [‎849‎ items ]

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